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Details on Person Addition of nucleotides leads to HIV-1 transcript elongation

Class:Id	Reaction:167181
_displayName	Addition of nucleotides leads to HIV-1 transcript elongation
_doRelease	TRUE
_timestamp	2021-11-03 19:06:18
authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167180] Matthews, L, 2005-10-12 16:51:27
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
edited	[InstanceEdit:165066] Matthews, L, 2005-07-26 23:29:22
figure	[Figure:113803] /figures/elong1.jpg
inferredFrom	[Reaction:112385] Addition of nucleotides leads to transcript elongation [Homo sapiens]
input	[Complex:167185] HIV-1 elongation complex containing Tat [nucleoplasm] [Homo sapiens] [SimpleEntity:9757634] NTP [nucleoplasm]
literatureReference	[LiteratureReference:113806] Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. [LiteratureReference:113805] Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
modified	[InstanceEdit:167232] Matthews, L, 2005-10-13 19:57:36 [InstanceEdit:167312] Matthews, L, 2005-10-15 11:44:29 [InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:170768] Matthews, L, 2006-01-15 13:04:15 [InstanceEdit:170793] Vastrik, I, 2006-01-16 05:24:48 [InstanceEdit:179408] Matthews, L, 2006-04-27 21:18:47 [InstanceEdit:2671731] D'Eustachio, P, 2012-11-23 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:6787528] D'Eustachio, Peter, 2015-07-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9757642] D'Eustachio, Peter, 2021-11-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Addition of nucleotides leads to HIV-1 transcript elongation
output	[Complex:167184] HIV-1 Tat-containing processive elongation complex [nucleoplasm] [Homo sapiens] [Complex:109634] TFIIH [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:167196] Recruitment of elongation factors to form HIV-1 elongation complex [Homo sapiens] [Reaction:112436] Formation of Elongin complex [Homo sapiens] [Reaction:112429] Formation of FACT complex [Homo sapiens] [Reaction:170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361018] R-HSA-167181.5
summation	[Summation:170761] This HIV-1 event was inferred from the corresponding human R...
(hasEvent)	[Pathway:167246] Tat-mediated elongation of the HIV-1 transcript [Homo sapiens]
(precedingEvent)	[Reaction:167076] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing [Homo sapiens] [Reaction:167090] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest [Homo sapiens] [Reaction:167192] Pol II elongation complex moves on the HIV-1 template as transcript elongates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775491] Update Tracker - [Reaction:167181] Addition of nucleotides leads to HIV-1 transcript elongation - v79:[add_removeInput] [_UpdateTracker:9784214] Update Tracker - [Reaction:167181] Addition of nucleotides leads to HIV-1 transcript elongation - v54:[addLiteratureReference]
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