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Details on Person Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition

Class:Id	BlackBoxEvent:167113
_displayName	Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
_doRelease	TRUE
_timestamp	2021-11-03 19:06:19
authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
catalystActivity	[CatalystActivity:109910] DNA-directed RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167126] Matthews, L, 2005-10-11 08:30:05
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
edited	[InstanceEdit:165066] Matthews, L, 2005-07-26 23:29:22
inferredFrom	[BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition [Homo sapiens]
input	[Complex:167119] HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] [Homo sapiens] [SimpleEntity:9757634] NTP [nucleoplasm]
literatureReference	[LiteratureReference:110387] Three transitions in the RNA polymerase II transcription complex during initiation. [LiteratureReference:111262] Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape.
modified	[InstanceEdit:167261] Matthews, L, 2005-10-13 20:52:12 [InstanceEdit:167328] Matthews, L, 2005-10-15 11:53:41 [InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:170793] Vastrik, I, 2006-01-16 05:24:48 [InstanceEdit:194432] Schmidt, EE, 2007-03-13 12:36:16 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:6787506] D'Eustachio, Peter, 2015-07-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9613503] Gillespie, Marc E, 2018-07-13 [InstanceEdit:9757642] D'Eustachio, Peter, 2021-11-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
output	[EntityWithAccessionedSequence:65888] GTF2B [nucleoplasm] [Homo sapiens] [SimpleEntity:113541] PPi [nucleoplasm] [Complex:167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9613490] Unwinding of DNA for the nascent HIV-1 transcript: Second Transition [Homo sapiens] [BlackBoxEvent:167121] Addition of the third nucleotide on the nascent HIV-1 transcript [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359761] R-HSA-167113.6
summation	[Summation:111274] Formation of the third phosphodiester bond creates a 4-nt p...
(hasEvent)	[Pathway:167162] RNA Polymerase II HIV Promoter Escape [Homo sapiens]
(precedingEvent)	[Reaction:167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript [Homo sapiens] [Reaction:167474] Abortive HIV-1 Initiation Before Second Transition [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775348] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v79:[add_removeInput] [_UpdateTracker:9779066] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v66:[removeCatalystActivity] [_UpdateTracker:9784146] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v54:[addLiteratureReference, modifyText] [_UpdateTracker:9784677] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v53:[modifyText] [_UpdateTracker:9789679] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v37:[modifyText]
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