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Details on Person SHC binds to the activated TrkA receptor

Class:Id	Reaction:167056
_displayName	SHC binds to the activated TrkA receptor
_doRelease	TRUE
_timestamp	2024-03-18 20:06:29
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:167064] 2006-02-07 08:34:19
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
inferredFrom	[Reaction:181835] Shc binds to active Trk receptor [Rattus norvegicus]
input	[Complex:166540] Activated TrkA receptor complex [plasma membrane] [Homo sapiens] [DefinedSet:167023] SHC [cytosol] [Homo sapiens]
modified	[InstanceEdit:167212] 2006-02-07 08:34:20 [InstanceEdit:167673] Jassal, Bijay, 2005-11-01 [InstanceEdit:169684] Jassal, Bijay, 2005-11-30 [InstanceEdit:181805] Jassal, Bijay, 2006-06-20 [InstanceEdit:187730] Jassal, Bijay, 2006-09-21 [InstanceEdit:187903] Jassal, Bijay, 2006-09-29 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188624] Jassal, Bijay, 2006-10-19 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:1806831] Jassal, B, 2011-10-24 [InstanceEdit:2018637] Jassal, Bijay, 2011-11-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
name	SHC binds to the activated TrkA receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865761] Futile Cycle: Active PLCG1 dissociates from TrkA receptor
output	[Complex:167020] Activated TrkA receptor:SHC [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:166544] TrkA receptor autophosphorylates [Homo sapiens] [Reaction:166538] The bound receptor dimerizes [Homo sapiens] [Reaction:167217] Phospho-Shc dissociates from the TrkA receptor [Homo sapiens] [Reaction:167019] SHC, complexed with TrkA, is tyrosine-phosphorylated [Homo sapiens]
releaseDate	2007-12-11
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359438] R-HSA-167056.3
summation	[Summation:169679] SHC proteins (SHC 1, 2, 3) are signalling adapters, able to ...
(hasEvent)	[Pathway:167044] Signalling to RAS [Homo sapiens]
(precedingEvent)	[Reaction:167019] SHC, complexed with TrkA, is tyrosine-phosphorylated [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789022] Update Tracker - [Reaction:167056] SHC binds to the activated TrkA receptor - v39:[modifyText]
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