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Details on Person TRAF6 binds MEKK1

Class:Id	Reaction:166869
_displayName	TRAF6 binds MEKK1
_doRelease	TRUE
_timestamp	2012-11-19 17:31:40
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:166870] de Bono, B, 2005-09-21 11:32:08
edited	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
input	[EntityWithAccessionedSequence:166866] MAP3K1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:166872] ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway [LiteratureReference:933487] Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
modified	[InstanceEdit:166871] de Bono, B, 2005-09-21 11:32:49 [InstanceEdit:168971] de Bono, B, 2005-11-22 19:37:29 [InstanceEdit:169801] de Bono, B, 2005-12-07 10:35:14 [InstanceEdit:169803] de Bono, B, 2005-12-07 10:37:43 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:181970] de Bono, B, 2006-07-04 13:11:57 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:946514] Shamovsky, V, 2010-09-06 [InstanceEdit:975219] Shamovsky, V, 2010-09-22 [InstanceEdit:975884] Shamovsky, V, 2010-10-06 [InstanceEdit:1014292] Shamovsky, V, 2010-11-15 [InstanceEdit:1080813] D'Eustachio, P, 2010-11-27 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:2603286] Shamovsky, V, 2012-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binds MEKK1
output	[Complex:166867] MEKK1:activated TRAF6 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens] [Reaction:166363] TRAF6 binds to hp- IRAK1 [Homo sapiens] [Reaction:975879] Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex [Homo sapiens] [Reaction:975857] TRAF6 binds to hp- IRAK1 or p-IRAK2 [Homo sapiens]
regulatedBy	[Requirement:181968] Requirement by 'ECSIT [cytosol]'
regulationReference	[RegulationReference:9641636] Requirement by 'ECSIT [cytosol]' Ecsit-ement on the crossroads of Toll and BMP signal transduction
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360431] R-HSA-166869.4
summation	[Summation:169804] TRAF6 binding to MAPK kinase kinase 1 (MEKK1) is mediated by...
(hasEvent)	[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens] [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [Homo sapiens] [Pathway:975871] MyD88 cascade initiated on plasma membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788167] Update Tracker - [Reaction:166869] TRAF6 binds MEKK1 - v43:[modifyText] [_UpdateTracker:9791901] Update Tracker - [Reaction:166869] TRAF6 binds MEKK1 - v25:[add_removeRegulator]
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