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Details on Person UniProt:Q5T1C6 THEM4
| Class:Id | ReferenceGeneProduct:166804 |
|---|---|
| _chainChangeLog | transit peptide:1-36 added on Fri February 6 2015;chain:37-240 added on Fri February 6 2015 |
| _displayName | UniProt:Q5T1C6 THEM4 |
| _timestamp | 2025-02-21 18:42:49 |
| chain | transit peptide:1-36 chain:37-240 |
| checksum | A01071B07A1B5FB2 |
| comment | FUNCTION Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)CATALYTIC ACTIVITY octanoyl-CoA + H2O = octanoate + CoA + H(+)CATALYTIC ACTIVITY decanoyl-CoA + H2O = decanoate + CoA + H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)CATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES Homodimer and homotetramer. Interacts with AKT1 in the cytosol.INTERACTION Released from the mitochondria into the cytosol in response to apoptotic stimuli.TISSUE SPECIFICITY Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.PTM Phosphorylated.SIMILARITY Belongs to the THEM4/THEM5 thioesterase family. |
| created | [InstanceEdit:166803] Schmidt, EE, 2005-09-16 14:44:46 |
| description | recommendedName: Acyl-coenzyme A thioesterase THEM4 shortName: Acyl-CoA thioesterase THEM4 ecNumber evidence="11 14"3.1.2.2 alternativeName: Carboxyl-terminal modulator protein alternativeName: Thioesterase superfamily member 4 |
| geneName | THEM4 CTMP |
| identifier | Q5T1C6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Apoptosis Cell membrane Cell projection Cytoplasm Fatty acid metabolism Hydrolase Lipid metabolism Membrane Mitochondrion Mitochondrion inner membrane Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | THEM4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993942] ENSEMBL:ENSG00000159445 THEM4 [Homo sapiens] |
| secondaryIdentifier | THEM4_HUMAN B2RBX2 Q96KR2 |
| sequenceLength | 240 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:162408] THEM4 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:199437] THEM4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6809345] THEM4 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5T1C6 THEM4 (166804)
