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Details on Person Formation of Classical C3 convertase (C4b:C2a complex)

Class:Id	Reaction:166795
_displayName	Formation of Classical C3 convertase (C4b:C2a complex)
_doRelease	TRUE
_timestamp	2016-11-10 00:55:48
authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166794] de Bono, B, 2005-09-16 12:40:20
edited	[InstanceEdit:1022119] Jupe, S, 2010-11-17
input	[EntityWithAccessionedSequence:166780] C2a [extracellular region] [Homo sapiens] [Complex:981716] Cell surface:C4b [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:182436] Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement
modified	[InstanceEdit:166797] de Bono, B, 2005-09-16 12:43:32 [InstanceEdit:173526] de Bono, B, 2006-02-14 06:30:05 [InstanceEdit:173553] de Bono, B, 2006-02-14 11:36:31 [InstanceEdit:173727] de Bono, B, 2006-02-16 12:31:35 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177476] Gopinathrao, G, 2006-03-30 22:02:42 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:182442] de Bono, B, 2006-07-10 14:01:38 [InstanceEdit:182626] de Bono, B, 2006-07-11 10:06:04 [InstanceEdit:182632] de Bono, B, 2006-07-11 11:32:42 [InstanceEdit:981538] Jupe, S, 2010-10-22 [InstanceEdit:981647] Jupe, S, 2010-10-26 [InstanceEdit:981705] Jupe, S, 2010-10-26 [InstanceEdit:1022120] Jupe, S, 2010-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of Classical C3 convertase (C4b:C2a complex)
output	[Complex:166784] Cell surface:C4b:C2a [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:166792] Conversion of C2 into C2a and C2b [Homo sapiens] [Reaction:166726] Activation of MASPs [Homo sapiens] [Reaction:981713] C4b binds to cell surface [Homo sapiens] [Reaction:166753] Conversion of C4 into C4a and C4b [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:981693] Jupe, S, 2010-10-26
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361812] R-HSA-166795.3
summation	[Summation:182443] C4b and C2a form a complex termed the classical pathway C3 c...
(hasEvent)	[Pathway:166663] Initial triggering of complement [Homo sapiens]
(inferredFrom)	[Reaction:2132096] Formation of C4b:factor B complex [Gallus gallus]
(precedingEvent)	[Reaction:166817] Cleavage of C3 by C3 convertases [Homo sapiens] [Reaction:977375] CR1 binds C3bBb/C4bC2a [Homo sapiens] [Reaction:981535] CD55 (DAF) binds C3bBb, C4bC2a [Homo sapiens] [Reaction:981621] C3 convertases spontaneously dissociate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790123] Update Tracker - [Reaction:166795] Formation of Classical C3 convertase (C4b:C2a complex) - v35:[add_removeInput]
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No pathways have been reviewed or authored by Formation of Classical C3 convertase (C4b:C2a complex) (166795)