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Details on Person Conversion of C2 into C2a and C2b

Class:Id	Reaction:166792
_displayName	Conversion of C2 into C2a and C2b
_doRelease	TRUE
_timestamp	2016-11-10 00:55:00
authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
catalystActivity	[CatalystActivity:166764] serine-type endopeptidase activity of C4 activators [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166791] de Bono, B, 2005-09-16 12:35:57
input	[EntityWithAccessionedSequence:166778] C2 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:166769] The biological functions of MBL-associated serine proteases (MASPs) [LiteratureReference:182412] Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2 [LiteratureReference:182438] Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b [LiteratureReference:182436] Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement
modified	[InstanceEdit:174572] de Bono, B, 2006-02-20 14:58:32 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177476] Gopinathrao, G, 2006-03-30 22:02:42 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:182435] de Bono, B, 2006-07-10 13:39:13 [InstanceEdit:182626] de Bono, B, 2006-07-11 10:06:04 [InstanceEdit:182632] de Bono, B, 2006-07-11 11:32:42 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Conversion of C2 into C2a and C2b
output	[EntityWithAccessionedSequence:166780] C2a [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:166781] C2b [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:166726] Activation of MASPs [Homo sapiens] [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa [Homo sapiens] [Reaction:2855125] Ficolin-1 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:2855054] Ficolin-2 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:2855077] Ficolin-3 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:8852509] CL-LK binds carbohydrates on target cell surface [Homo sapiens] [Reaction:9957161] MBL2 binds SARS-CoV-2 S [Homo sapiens]
releaseDate	2006-08-02
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361715] R-HSA-166792.3
summation	[Summation:174561] C2 is cleaved into the large C2a and the small C2b fragment....
(hasEvent)	[Pathway:166663] Initial triggering of complement [Homo sapiens]
(precedingEvent)	[Reaction:166795] Formation of Classical C3 convertase (C4b:C2a complex) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788873] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v40:[modifyText] [_UpdateTracker:9790033] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v35:[modifyText]
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