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Details on Person Conversion of C4 into C4a and C4b

Class:Id	Reaction:166753
_displayName	Conversion of C4 into C4a and C4b
_doRelease	TRUE
_timestamp	2016-11-10 00:55:46
authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
catalystActivity	[CatalystActivity:166764] serine-type endopeptidase activity of C4 activators [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166752] de Bono, B, 2005-09-16 11:55:48
edited	[InstanceEdit:1011624] Jupe, S, 2010-11-11
input	[DefinedSet:981697] Complement Factor 4 [extracellular region] [Homo sapiens] [DefinedSet:981697] Complement Factor 4 [extracellular region] [Homo sapiens] [DefinedSet:981697] Complement Factor 4 [extracellular region] [Homo sapiens] [DefinedSet:981697] Complement Factor 4 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:166709] The lectin-complement pathway--its role in innate immunity and evolution [LiteratureReference:166769] The biological functions of MBL-associated serine proteases (MASPs) [LiteratureReference:182432] C'1 esterase effect on activity and physicochemical properties of the fourth component of complement
modified	[InstanceEdit:166765] de Bono, B, 2005-09-16 12:03:21 [InstanceEdit:166767] de Bono, B, 2005-09-16 12:09:33 [InstanceEdit:166791] de Bono, B, 2005-09-16 12:35:57 [InstanceEdit:173633] de Bono, B, 2006-02-15 12:00:51 [InstanceEdit:174571] de Bono, B, 2006-02-20 14:58:13 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177476] Gopinathrao, G, 2006-03-30 22:02:42 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:182434] de Bono, B, 2006-07-10 13:34:50 [InstanceEdit:182626] de Bono, B, 2006-07-11 10:06:04 [InstanceEdit:182632] de Bono, B, 2006-07-11 11:32:42 [InstanceEdit:981647] Jupe, S, 2010-10-26 [InstanceEdit:981705] Jupe, S, 2010-10-26 [InstanceEdit:1022107] Jupe, S, 2010-11-17 [InstanceEdit:1022118] Jupe, S, 2010-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Conversion of C4 into C4a and C4b
output	[DefinedSet:981725] C4a [extracellular region] [Homo sapiens] [DefinedSet:981725] C4a [extracellular region] [Homo sapiens] [DefinedSet:981725] C4a [extracellular region] [Homo sapiens] [DefinedSet:981700] C4b [extracellular region] [Homo sapiens] [DefinedSet:981700] C4b [extracellular region] [Homo sapiens] [DefinedSet:981700] C4b [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:166726] Activation of MASPs [Homo sapiens] [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa [Homo sapiens] [Reaction:2855125] Ficolin-1 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:2855054] Ficolin-2 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:2855077] Ficolin-3 binds to molecular patterns on the target cell surface [Homo sapiens] [Reaction:8852509] CL-LK binds carbohydrates on target cell surface [Homo sapiens] [Reaction:9957161] MBL2 binds SARS-CoV-2 S [Homo sapiens] [Reaction:173631] Activation of C1s [Homo sapiens] [Reaction:173626] Activation of C1r [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:981693] Jupe, S, 2010-10-26
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360694] R-HSA-166753.3
summation	[Summation:174562] The alpha chain of C4 is cleaved, releasing an N-terminal po...
(hasEvent)	[Pathway:166663] Initial triggering of complement [Homo sapiens] [Pathway:166748] Activation of C4 [Homo sapiens]
(precedingEvent)	[Reaction:981713] C4b binds to cell surface [Homo sapiens] [Reaction:2855047] Hydrolysis of internal thioester in C4b [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790098] Update Tracker - [Reaction:166753] Conversion of C4 into C4a and C4b - v35:[add_removeInput, add_removeOutput, modifyText]
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