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Details on Person MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa

Class:Id	Reaction:166721
_displayName	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
_doRelease	TRUE
_timestamp	2016-11-10 00:57:05
authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166722] de Bono, B, 2005-09-15 14:24:26
input	[Complex:166710] MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] [Homo sapiens] [OtherEntity:166718] Bacterial mannose surface pattern [plasma membrane] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region]
literatureReference	[LiteratureReference:182411] Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition [LiteratureReference:166677] The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases [LiteratureReference:166709] The lectin-complement pathway--its role in innate immunity and evolution [LiteratureReference:174542] The mannan-binding lectin pathway of complement activation: biology and disease association
modified	[InstanceEdit:166754] de Bono, B, 2005-09-16 11:56:35 [InstanceEdit:174573] de Bono, B, 2006-02-20 15:00:25 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177476] Gopinathrao, G, 2006-03-30 22:02:42 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:182430] de Bono, B, 2006-07-10 13:23:33 [InstanceEdit:182626] de Bono, B, 2006-07-11 10:06:04 [InstanceEdit:182632] de Bono, B, 2006-07-11 11:32:42 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:3266560] Shamovsky, V, 2013-04-10 [InstanceEdit:8852519] Jupe, Steve, 2016-01-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
output	[Complex:166719] MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359953] R-HSA-166721.4
summation	[Summation:182428] The MBL polypeptide chain consists of a short N-terminal cys...
(hasEvent)	[Pathway:166662] Lectin pathway of complement activation [Homo sapiens]
(precedingEvent)	[Reaction:166726] Activation of MASPs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783594] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v56:[modifyText] [_UpdateTracker:9787454] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v45:[addLiteratureReference, modifyText]
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