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Details on Person Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)

Class:Id	Reaction:1667005
_displayName	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
_doRelease	TRUE
_timestamp	2025-03-12 10:04:17
authored	[InstanceEdit:2024092] Jassal, B, 2011-12-14
catalystActivity	[CatalystActivity:1666996] heparanase activity of HPSE dimer [lysosomal lumen]
catalystActivityReference	[CatalystActivityReference:9774585] heparanase activity of HPSE dimer [lysosomal lumen] Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1666994] Jassal, B, 2011-10-14
edited	[InstanceEdit:2024092] Jassal, B, 2011-12-14
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [DefinedSet:2090050] HS/HPIN-PGs [lysosomal lumen] [Homo sapiens]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:1666991] Human heparanase is localized within lysosomes in a stable form [LiteratureReference:1667007] Heterodimer formation is essential for heparanase enzymatic activity [LiteratureReference:9774579] Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence [LiteratureReference:1666987] Human heparanase. Purification, characterization, cloning, and expression
modified	[InstanceEdit:1678699] Jassal, B, 2011-10-19 [InstanceEdit:1793189] Jassal, B, 2011-10-21 [InstanceEdit:1793232] Jassal, B, 2011-10-21 [InstanceEdit:2022170] Jassal, B, 2011-11-28 [InstanceEdit:2024092] Jassal, B, 2011-12-14 [InstanceEdit:2090024] Jassal, B, 2012-02-06 [InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:9774581] D'Eustachio, Peter, 2022-05-25 [InstanceEdit:9792575] D'Eustachio, Peter, 2022-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12
name	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
output	[SimpleEntity:2090033] IdoA-GlcN6S-IdoA2S-GlcN3S- group [lysosomal lumen] [DefinedSet:2076551] GlcA-Gal-Gal-Xyl-HS proteins [Golgi lumen] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation [Homo sapiens] [BlackBoxEvent:2024108] Some HSPGs are secreted to the plasma membrane [Homo sapiens] [BlackBoxEvent:9792568] CTSL1 cleaves proHPSE [Homo sapiens] [Reaction:9941078] proHPSE dissociates from HS(6)-SDC1 [Homo sapiens] [Reaction:9941078] proHPSE dissociates from HS(6)-SDC1 [Homo sapiens] [BlackBoxEvent:9792581] proHPSE:SDC1 is delivered to lysosomes [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295235] R-HSA-1667005.4
structureModified	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation	[Summation:1666979] Heparanase (HPSE) is an endoglycosidase that cleaves heparan...
(hasEvent)	[Pathway:2024096] HS-GAG degradation [Homo sapiens]
(precedingEvent)	[Reaction:1678716] IDUA cleaves iduronate from HS chain [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9847069] Update Tracker - [Reaction:1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - v82:[addLiteratureReference, modifyText] [_UpdateTracker:9953716] Update Tracker - [Reaction:1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - v93:[add_removeOutput, modifyText]
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