Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Proteins carrying a heparan sulfate (HS) chain are called he...
| Class:Id | Summation:1666999 |
|---|---|
| _displayName | Proteins carrying a heparan sulfate (HS) chain are called he... |
| _timestamp | 2025-03-07 10:45:42 |
| created | [InstanceEdit:1666994] Jassal, B, 2011-10-14 |
| modified | [InstanceEdit:1678699] Jassal, B, 2011-10-19 [InstanceEdit:1971508] Jassal, B, 2011-11-04 [InstanceEdit:2022170] Jassal, B, 2011-11-28 [InstanceEdit:2022912] Jassal, B, 2011-12-01 [InstanceEdit:2024092] Jassal, B, 2011-12-14 [InstanceEdit:9941465] Stephan, Ralf, 2025-03-07 |
| text | Proteins carrying a heparan sulfate (HS) chain are called heparan sulfate proteoglycans (HSPG). Free HS is usually stored within the secretory granules of mast cells or cleaved from HSPGs on degradation. HS is a member of the glycosaminoglycan (GAG) family and consists of the variably sulfated repeating disaccharide units heparan (Ido-GlcNAc) or heparosan (GlcA-GlcNAc). Higher degrees of sulfation and iduronic acid content in the polysaccharide chain confers the name heparin rather than heparan sulfate to the chain. Two or three HS chains attach to a core protein on the cell surface or in the extracellular matrix (Sasisekharan & Venkataraman 2000). HS bound to a core protein can regulate many biological processes such as angiogenesis, blood coagulation and tumour metastasis (Stringer & Gallagher 1997, Tumova et al. 2000). Degradation of HS is required to maintain a natural turnover of GAGs. Defects in the degradative enzymes result in lysosomal storage diseases, where GAGs build up rather than being broken down and having pathological effects (Ballabio & Gieselmann 2009). |
| (summation) | [Pathway:1638091] Heparan sulfate/heparin (HS-GAG) metabolism [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Proteins carrying a heparan sulfate (HS) chain are called he... (1666999)
