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Details on Person The MyD88-independent signaling pathway is shared by TLR3 an...
| Class:Id | Summation:166412 |
|---|---|
| _displayName | The MyD88-independent signaling pathway is shared by TLR3 an... |
| _timestamp | 2023-07-10 05:33:41 |
| created | [InstanceEdit:166414] de Bono, B, 2005-08-30 11:59:13 |
| literatureReference | [LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway [LiteratureReference:434112] TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction [LiteratureReference:165861] TRAM is specifically involved in the Toll-like receptor 4-mediated [LiteratureReference:975473] Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling [LiteratureReference:975477] TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta |
| modified | [InstanceEdit:975202] Shamovsky, V, 2010-09-22 [InstanceEdit:975490] Shamovsky, V, 2010-09-24 [InstanceEdit:2201353] Shamovsky, V, 2012-04-19 [InstanceEdit:3322159] Shamovsky, V, 2013-05-03 [InstanceEdit:3621901] Shamovsky, V, 2013-05-24 [InstanceEdit:9839731] Shamovsky, Veronica, 2023-07-10 |
| text | The MyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from TLR3 and TLR4 in a MyD88-independent manner (Yamamoto M et al. 2003a). TRIF is recruited to the ligand-stimulated TLR3 or 4 complex via its TIR domain. TLR3 directly binds TRIF (Oshiumi H et al 2003). In contrast, the TLR4-mediated signaling pathway requires two adapter molecules, TRAM (TRIF-related adapter molecule or TICAM2) and TRIF. TRAM(TICAM2) is thought to bridge the activated TLR4 complex and TRIF (Yamamoto M et al. 2003b, Tanimura N et al. 2008, Kagan LC et al. 2008). TRIF recruitment to the TLR complex stimulates distinct pathways leading to the production of type I interferons (IFNs) and pro-inflammatory cytokines and to the induction of programmed cell death. |
| (summation) | [Pathway:166166] MyD88-independent TLR4 cascade [Homo sapiens] |
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