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Details on Person TRAF6 [cytosol]
Class:Id EntityWithAccessionedSequence:166366
_displayName TRAF6 [cytosol]
_timestamp 2010-09-10 10:31:48
compartment [Compartment:70101] cytosol
created [InstanceEdit:166365] de Bono, B, 2005-08-23 14:28:10
endCoordinate 522
modified [InstanceEdit:202494] Garapati, P V, 2007-10-30 16:05:12 [InstanceEdit:204876] Garapati, P V, 2007-12-03 14:31:21 [InstanceEdit:205142] Jassal, B, 2007-12-06 11:28:58 [InstanceEdit:352306] Jassal, B, 2008-06-02 09:53:24 [InstanceEdit:450149] Jupe, S, 2009-12-16
name TRAF6
referenceEntity [ReferenceGeneProduct:103764] UniProt:Q9Y4K3 TRAF6 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:366106] R-HSA-166366.1
startCoordinate 1
(activeUnit) [CatalystActivity:203801] ubiquitin-protein transferase activity of TRAF6 trimer bound to CBM complex [plasma membrane] [CatalystActivity:450164] ubiquitin-protein transferase activity of hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] [CatalystActivity:2730897] ubiquitin-protein transferase activity of DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane] [CatalystActivity:2730906] ubiquitin-protein transferase activity of DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] [CatalystActivity:5607717] ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] [CatalystActivity:5607718] ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] [CatalystActivity:9645438] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] [CatalystActivity:9749449] ubiquitin-protein transferase activity of TRAF6:NLRX1 [cytosol]
(hasComponent) [Complex:166367] p-5S,2T-IRAK1:TRAF6 [cytosol] [Homo sapiens] [Complex:166867] MEKK1:activated TRAF6 [cytosol] [Homo sapiens] [Complex:167977] IRAK -P:TRAF6 [cytosol] [Homo sapiens] [Complex:193877] mature NGF:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] [Homo sapiens] [Complex:193912] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] [Homo sapiens] [Complex:193917] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi:IKK-beta [plasma membrane] [Homo sapiens] [Complex:193940] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi:Phospho-IKK-beta [plasma membrane] [Homo sapiens] [Complex:193945] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] [Homo sapiens] [Complex:194374] mature NGF:p75NTR:NRIF:TRAF6 [plasma membrane] [Homo sapiens] [Complex:197481] NF-kB:p75NTR ICD:TRAF6 [cytosol] [Homo sapiens]
(hasMember) [DefinedSet:194372] JNK activators [cytosol] [Homo sapiens] [DefinedSet:918188] TRAF2, TRAF6 [cytosol] [Homo sapiens] [DefinedSet:5690846] RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] [Homo sapiens] [DefinedSet:6782832] TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] [Homo sapiens] [DefinedSet:6782842] TRAF2,TRAF6,DDX58 [cytosol] [Homo sapiens]
(input) [Reaction:166363] TRAF6 binds to hp- IRAK1 [Homo sapiens] [Reaction:166869] TRAF6 binds MEKK1 [Homo sapiens] [Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 [Homo sapiens] [Reaction:193695] IRAK interacts with TRAF6 [Homo sapiens] [Reaction:193700] p75NTR ICD signals to NF-kB [Homo sapiens] [Reaction:202472] Translocation of TRAF6 to CBM complex [Homo sapiens] [Reaction:446862] Hyperphosphorylated IRAK1 associates with TRAF6 [Homo sapiens] [Reaction:450173] IRAK1 induces oligomerisation of TRAF6 [Homo sapiens] [Reaction:507719] p62:MEKK3 binds to TRAF6 [Homo sapiens] [Reaction:936963] IRAK2 induces TRAF6 oligomerization [Homo sapiens]
(physicalEntity) [CatalystActivity:208932] ubiquitin-protein transferase activity of TRAF6 [cytosol]
(repeatedUnit) [Polymer:2685708] TRAF6 oligomer [cytosol] [Homo sapiens]
(updatedInstance) [_UpdateTracker:9866635] Update Tracker - [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] - v24:[addEndCoordinate, addStartCoordinate] [_UpdateTracker:9867691] Update Tracker - [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] - v25:[modifyEndCoordinate]
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Pathways
No pathways have been reviewed or authored by TRAF6 [cytosol] (166366)