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Details on Person TRAF6 binds to hp- IRAK1

Class:Id	Reaction:166363
_displayName	TRAF6 binds to hp- IRAK1
_doRelease	TRUE
_timestamp	2014-08-29 16:40:27
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:166364] de Bono, B, 2005-08-23 14:27:06
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input	[EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [Complex:166360] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB [LiteratureReference:446876] TRAF6 is a signal transducer for interleukin-1 [LiteratureReference:165903] Identification of threonine 66 as a functionally critical residue of the [LiteratureReference:450151] Distinct molecular mechanism for initiating TRAF6 signalling
modified	[InstanceEdit:166369] de Bono, B, 2005-08-23 14:31:37 [InstanceEdit:168971] de Bono, B, 2005-11-22 19:37:29 [InstanceEdit:169799] de Bono, B, 2005-12-07 10:18:07 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:937111] Shamovsky, V, 2010-08-25 [InstanceEdit:1018390] Shamovsky, V, 2010-11-16 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:1551951] Shamovsky, V, 2011-08-30 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2262781] Shamovsky, V, 2012-05-21 [InstanceEdit:2603287] Shamovsky, V, 2012-11-19 [InstanceEdit:2627685] Shamovsky, V, 2012-11-19 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binds to hp- IRAK1
output	[Complex:937053] TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:166286] Multiple IRAK1 autophosphorylation steps [Homo sapiens] [Reaction:166284] Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP [Homo sapiens]
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359833] R-HSA-166363.2
summation	[Summation:446863] Hyperphosphorylated IRAK1, still within the receptor complex...
(hasEvent)	[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(inferredFrom)	[Reaction:434053] TRAF6 binds to p-IRAK2 complexed with activated TLR [Gallus gallus]
(precedingEvent)	[Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788581] Update Tracker - [Reaction:166363] TRAF6 binds to hp- IRAK1 - v41:[add_removeInput, modifyText, removeSummation]
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