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Details on Person Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex

Class:IdReaction:166362
_displayNameDissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
_doReleaseTRUE
_timestamp2018-08-09 02:29:45
authored[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:166364] de Bono, B, 2005-08-23 14:27:06
edited[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input[Complex:937053] TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
modified[InstanceEdit:166369] de Bono, B, 2005-08-23 14:31:37
[InstanceEdit:166370] de Bono, B, 2005-08-23 14:32:16
[InstanceEdit:169779] de Bono, B, 2005-12-06 15:45:30
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:181398] de Bono, B, 2006-06-09 10:18:34
[InstanceEdit:181963] de Bono, B, 2006-07-04 10:34:57
[InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15
[InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:937090] Shamovsky, V, 2010-08-25
[InstanceEdit:940395] Shamovsky, V, 2010-09-02
[InstanceEdit:1013005] Shamovsky, V, 2010-11-11
[InstanceEdit:1018389] Shamovsky, V, 2010-11-16
[InstanceEdit:1095194] Shamovsky, V, 2010-11-30
[InstanceEdit:1495949] Shamovsky, V, 2011-08-16
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2262780] Shamovsky, V, 2012-05-21
[InstanceEdit:2603263] Shamovsky, V, 2012-11-19
[InstanceEdit:2627684] Shamovsky, V, 2012-11-19
[InstanceEdit:5621482] Shamovsky, V, 2014-08-29
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
output[Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] [Homo sapiens]
[Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] [Homo sapiens]
[Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] [Homo sapiens]
[Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] [Homo sapiens]
[Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:166139] Negative regulation by 'IRAK3 [cytosol]'
regulationReference[RegulationReference:9642138] Negative regulation by 'IRAK3 [cytosol]' IRAK-M is a negative regulator of Toll-like receptor signaling
relatedSpecies[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:937065] Shamovsky, V, 2010-08-25
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361923] R-HSA-166362.5
summation[Summation:940394] Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociat...
(hasEvent)[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(inferredFrom)[Reaction:434084] p-IRAK2- TRAF6 dissociates from the activated chTLR complex [Gallus gallus]
(precedingEvent)[Reaction:166869] TRAF6 binds MEKK1 [Homo sapiens]
[Reaction:936963] IRAK2 induces TRAF6 oligomerization [Homo sapiens]
[Reaction:937044] Pellino binds hp-IRAK1:TRAF6 [Homo sapiens]
[Reaction:975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788211] Update Tracker - [Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - v43:[modifyText]
[_UpdateTracker:9788642] Update Tracker - [Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - v41:[add_removeOutput, modifyText]
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