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Details on Person Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Class:Id Reaction:166284 _displayName Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP _doRelease TRUE _timestamp 2018-08-09 02:30:55 authored [InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15 catalystActivity [CatalystActivity:937069] protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:166283] de Bono, B, 2005-08-23 10:48:00 edited [InstanceEdit:2562589] Shamovsky, V, 2012-11-06 input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:166118] p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens] literatureReference [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling modified [InstanceEdit:169776] de Bono, B, 2005-12-06 15:42:13 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:181398] de Bono, B, 2006-06-09 10:18:34 [InstanceEdit:181963] de Bono, B, 2006-07-04 10:34:57 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04 [InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:937109] Shamovsky, V, 2010-08-25 [InstanceEdit:1018390] Shamovsky, V, 2010-11-16 [InstanceEdit:1080813] D'Eustachio, P, 2010-11-27 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:1564972] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2603284] Shamovsky, V, 2012-11-19 [InstanceEdit:2627685] Shamovsky, V, 2012-11-19 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:166281] pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens] precedingEvent
relatedSpecies [Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis releaseDate 2010-12-14 reviewed [InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:358664] R-HSA-166284.3 summation [Summation:169777] Second, Thr387 in the activation loop is phosphorylated, lea... (hasEvent) [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens] (precedingEvent) [Reaction:166286] Multiple IRAK1 autophosphorylation steps [Homo sapiens]
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