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Details on Person IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4

Class:Id	Reaction:166271
_displayName	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
_doRelease	TRUE
_timestamp	2024-02-23 00:47:40
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:166270] de Bono, B, 2005-08-23 09:26:30
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input	[DefinedSet:450317] IRF3,IRF7 [cytosol] [Homo sapiens] [DefinedSet:450317] IRF3,IRF7 [cytosol] [Homo sapiens] [DefinedSet:936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166253] Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical [LiteratureReference:2569068] SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
modified	[InstanceEdit:166273] de Bono, B, 2005-08-23 09:28:10 [InstanceEdit:166274] de Bono, B, 2005-08-23 09:28:49 [InstanceEdit:168385] Gillespie, ME, 2005-11-17 05:46:37 [InstanceEdit:168720] Gillespie, ME, 2005-11-17 06:26:18 [InstanceEdit:169821] de Bono, B, 2005-12-07 11:41:32 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:847695] Garapati, P V, 2010-05-30 [InstanceEdit:937097] Shamovsky, V, 2010-08-25 [InstanceEdit:1018389] Shamovsky, V, 2010-11-16 [InstanceEdit:1080813] D'Eustachio, P, 2010-11-27 [InstanceEdit:1095194] Shamovsky, V, 2010-11-30 [InstanceEdit:1564957] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201351] Shamovsky, V, 2012-04-19 [InstanceEdit:2213022] Shamovsky, V, 2012-04-27 [InstanceEdit:2569087] Shamovsky, V, 2012-11-12 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632485] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5483109] Shamovsky, V, 2014-05-16 [InstanceEdit:5492218] Shamovsky, V, 2014-05-20 [InstanceEdit:5566476] Shamovsky, V, 2014-05-23 [InstanceEdit:9013876] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9862122] Shamovsky, Veronica, 2024-02-23
name	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
output	[Complex:937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9823906] TBK1 is phosphorylated within the activated TLR4 complex [Homo sapiens] [Reaction:9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens] [Reaction:9824882] IKKε (IKBKE) is phosphorylated within the activated TLR4 complex [Homo sapiens] [Reaction:9823932] Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens]
regulatedBy	[NegativeRegulation:2569047] Negative regulation by 'PTPN11 [cytosol]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360967] R-HSA-166271.5
summation	[Summation:179335] Two members of the interferon regulatory factor (IRF) family... [Summation:2569067] SH2-containing protein tyrosine phosphatase 2 (SHP-2) has be...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(precedingEvent)	[Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex [Homo sapiens]
(replacementInstances)	[_Deleted:3371610] Deletion of instance: 168914
(updatedInstance)	[_UpdateTracker:9780671] Update Tracker - [Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - v62:[modifyText] [_UpdateTracker:9788229] Update Tracker - [Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - v43:[addLiteratureReference, addRegulator, addSummation] [_UpdateTracker:9846623] Update Tracker - [Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - v84:[modifyText]
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No pathways have been reviewed or authored by IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (166271)