Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person IRF3 [cytosol]

Class:IdEntityWithAccessionedSequence:166251
_displayNameIRF3 [cytosol]
_timestamp2025-02-17 23:13:42
compartment[Compartment:70101] cytosol
created[InstanceEdit:166250] de Bono, B, 2005-08-23 08:47:31
endCoordinate427
modified[InstanceEdit:3132750] Wu, G, 2013-02-13
[InstanceEdit:9729688] Stephan, Ralf, 2021-05-03
[InstanceEdit:9938525] D'Eustachio, Peter, 2025-02-17
nameIRF3
referenceEntity[ReferenceGeneProduct:57479] UniProt:Q14653 IRF3 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369446] R-HSA-166251.3
startCoordinate1
(hasComponent)[Complex:1169389] ISGylated IRF3 [cytosol] [Homo sapiens]
[Complex:1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] [Homo sapiens]
[Complex:1834956] STING:TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens]
[Complex:2396004] STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens]
[Complex:3465596] STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens]
[Complex:9709836] HSP90:TBK1:IRF3 [cytosol] [Homo sapiens]
[Complex:9731017] IRF3:8b [cytosol] [Homo sapiens]
[Complex:9731036] IRF3:nsp3 [cytosol] [Homo sapiens]
(hasMember)[DefinedSet:450317] IRF3,IRF7 [cytosol] [Homo sapiens]
[DefinedSet:1015695] IRF 1-9 [cytosol] [Homo sapiens]
(input)[Reaction:1169394] ISGylation of IRF3 [Homo sapiens]
[Reaction:1606345] Recruitment of IRF3 to activated ZBP1:TBK1 [Homo sapiens]
[Reaction:1834939] STING recruits TBK1 and IRF3 [Homo sapiens]
[Reaction:9709831] HSP90 binds TBK1 and IRF3 [Homo sapiens]
[Reaction:9729730] SARS-CoV-2 nsp3 cleaves IRF3 [Homo sapiens]
[Reaction:9731009] SARS-CoV-1 nsp3 binds to IRF3 [Homo sapiens]
[Reaction:9731077] SARS-CoV-1 8b binds to IRF3 [Homo sapiens]
[Reaction:9731441] RVA nsp1 binds IRF3 [Homo sapiens]
(output)[Reaction:9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9877399] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v44:[addEndCoordinate, addStartCoordinate]
[_UpdateTracker:9902242] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v77:[modifyStartCoordinate]
[_UpdateTracker:9940094] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v92:[modifyStartCoordinate]
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No pathways have been reviewed or authored by IRF3 [cytosol] (166251)