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Details on Person Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex

Class:Id	Reaction:166245
_displayName	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
_doRelease	TRUE
_timestamp	2014-05-23 04:17:28
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:937068] protein serine/threonine kinase activity of activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:166244] de Bono, B, 2005-08-23 08:43:35
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical
modified	[InstanceEdit:166249] de Bono, B, 2005-08-23 08:46:02 [InstanceEdit:166268] de Bono, B, 2005-08-23 09:19:16 [InstanceEdit:166862] de Bono, B, 2005-09-21 11:19:18 [InstanceEdit:168952] de Bono, B, 2005-11-22 18:52:15 [InstanceEdit:169819] de Bono, B, 2005-12-07 11:36:17 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04 [InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:937106] Shamovsky, V, 2010-08-25 [InstanceEdit:1018390] Shamovsky, V, 2010-11-16 [InstanceEdit:1080813] D'Eustachio, P, 2010-11-27 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:1564969] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201355] Shamovsky, V, 2012-04-19 [InstanceEdit:2213022] Shamovsky, V, 2012-04-27 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632486] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5483109] Shamovsky, V, 2014-05-16 [InstanceEdit:5492218] Shamovsky, V, 2014-05-20 [InstanceEdit:5566479] Shamovsky, V, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [DefinedSet:936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] [Homo sapiens] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 [Homo sapiens] [Reaction:9823906] TBK1 is phosphorylated within the activated TLR4 complex [Homo sapiens] [Reaction:9824882] IKKε (IKBKE) is phosphorylated within the activated TLR4 complex [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358449] R-HSA-166245.2
summation	[Summation:450284] Human IRF-3 is activated through a two step phosphorylation ...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(inferredFrom)	[Reaction:433786] Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 [Gallus gallus] [Reaction:433826] Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3 [Gallus gallus]
(precedingEvent)	[Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788198] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v43:[modifyText] [_UpdateTracker:9789354] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v38:[removeRegulator]
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