Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Raptor recruits mTORC to non-phosphorylated 4E-BP1 bound to ...

Class:IdSummation:166184
_displayNameRaptor recruits mTORC to non-phosphorylated 4E-BP1 bound to ...
_timestamp2025-11-29 06:08:16
created[InstanceEdit:166185] de Bono, B, 2005-08-22 12:11:48
literatureReference[LiteratureReference:165681] Signaling by target of rapamycin proteins in cell growth control
[LiteratureReference:1678806] eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
[LiteratureReference:5687991] Regulation of translation initiation by FRAP/mTOR
modified[InstanceEdit:166198] de Bono, B, 2005-08-22 12:28:49
[InstanceEdit:166199] de Bono, B, 2005-08-22 12:30:07
[InstanceEdit:166205] de Bono, B, 2005-08-22 13:00:47
[InstanceEdit:5687990] Jupe, Steve, 2015-04-13
[InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29
textRaptor recruits mTORC to non-phosphorylated 4E-BP1 bound to eIF4E and positively modulates phosphorylation of 4E-BP1 by mTORC. 4E-BP1 is further phosphorylated on multiple sites by other unknown kinases, also contributing to the dissociation of 4E-BP1 from eIF4E. Thus mTORC1 relieves the inhibitory effect of 4E-BP1 on eIF4E dependent translation initiation (Inoki et al. 2005, Gingras et al. 1999, 2001).
(summation)[Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Raptor recruits mTORC to non-phosphorylated 4E-BP1 bound to ... (166184)
Follow Reactome