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Details on Person Rheb is a GTP binding protein that exhibits GTPase activity....
| Class:Id | Summation:166180 |
|---|---|
| _displayName | Rheb is a GTP binding protein that exhibits GTPase activity.... |
| _timestamp | 2015-05-14 14:46:43 |
| created | [InstanceEdit:166181] de Bono, B, 2005-08-22 12:04:53 |
| literatureReference | [LiteratureReference:165681] Signaling by target of rapamycin proteins in cell growth control [LiteratureReference:5655429] mTOR: from growth signal integration to cancer, diabetes and ageing |
| modified | [InstanceEdit:166203] de Bono, B, 2005-08-22 12:52:31 [InstanceEdit:166204] de Bono, B, 2005-08-22 12:53:33 [InstanceEdit:5656349] Jupe, Steve, 2014-12-12 [InstanceEdit:5672033] Jupe, Steve, 2015-02-04 [InstanceEdit:5693184] Jupe, Steve, 2015-05-14 |
| text | Rheb is a GTP binding protein that exhibits GTPase activity. GDP is exchanged for GTP in the [Rheb:GDP] complex to form [Rheb:GTP], which binds and activates the mTORC1 complex. The GDP-bound form of Rheb also binds mTORC1 but does not lead to activation. This exchange may be catalysed by an as yet unidentified guanine exchange factor (GEF); the intrinsic exchange activity of Rheb may be sufficient in the absence of a GEF. |
| (summation) | [Reaction:165195] GTP loading by Rheb [Homo sapiens] |
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No pathways have been reviewed or authored by Rheb is a GTP binding protein that exhibits GTPase activity.... (166180)
