Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Class:Id	Complex:166172
_displayName	TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
_timestamp	2017-07-26 05:51:02
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:166171] de Bono, B, 2005-08-19 15:44:58
hasComponent	[Complex:166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:2201299] TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [SimpleEntity:2201311] LPS [endosome lumen] [SimpleEntity:2201311] LPS [endosome lumen] [EntityWithAccessionedSequence:2201284] GPIN-CD14(20-345) [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201284] GPIN-CD14(20-345) [endosome membrane] [Homo sapiens] [Complex:2201291] TLR4:LY96 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201307] LY96 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201285] TLR4 [endosome membrane] [Homo sapiens] [Complex:2201291] TLR4:LY96 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201307] LY96 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201285] TLR4 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201336] MyrG-p-S16-TICAM2 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201336] MyrG-p-S16-TICAM2 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:166170] TICAM1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166170] TICAM1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:2423800] Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling [LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters
modified	[InstanceEdit:937114] Shamovsky, V, 2010-08-25 [InstanceEdit:1018390] Shamovsky, V, 2010-11-16 [InstanceEdit:1604337] Shamovsky, V, 2011-09-14 [InstanceEdit:2201358] Shamovsky, V, 2012-04-19 [InstanceEdit:2248857] Shamovsky, V, 2012-05-15 [InstanceEdit:2423836] Shamovsky, V, 2012-07-20 [InstanceEdit:5676057] Shamovsky, Veronica, 2015-02-18 [InstanceEdit:9013873] Shamovsky, Veronica, 2017-07-26
name	TICAM1:TRAM:TLR4:LY96:LPS:CD14 TRIF:TRAM:TLR4:LY96:LPS:CD14
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:367817] R-HSA-166172.2
(hasComponent)	[Complex:168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:2213008] K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:2559578] SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Homo sapiens] [Complex:2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Homo sapiens] [Complex:2569054] RIP3:TICAM1:activated TLR4 [endosome membrane] [Homo sapiens]
(hasMember)	[CandidateSet:2569052] TRIF:activated TLR4 [endosome membrane] [Homo sapiens]
(input)	[Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens] [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 [Homo sapiens] [Reaction:2201338] TRAF3 binds TICAM1:activated TLR4 complex [Homo sapiens] [Reaction:2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 [Homo sapiens]
(output)	[Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) [Homo sapiens] [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Homo sapiens]
(regulator)	[Requirement:166248] Requirement by 'TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
(replacementInstances)	[_Deleted:9910833] Deletion of instance: 2201340
(updatedInstance)	[_UpdateTracker:9867591] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v25:[updateContainedComponent] [_UpdateTracker:9871327] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v39:[updateContainedComponent] [_UpdateTracker:9872135] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v41:[add_removeCompartment, add_removeHasComponent, modifyName, removeSpecies, updateContainedComponent] [_UpdateTracker:9873044] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [_UpdateTracker:9890150] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v52:[modifyName, updateContainedComponent] [_UpdateTracker:9897540] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v62:[addName]
[Change default viewing format]

No pathways have been reviewed or authored by TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (166172)