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Details on Person IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex

Class:IdReaction:166091
_displayNameIRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
_doReleaseTRUE
_timestamp2018-08-09 02:29:56
authored[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:166092] de Bono, B, 2005-08-17 10:27:50
edited[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory
[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
[LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
[LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
[LiteratureReference:2428843] Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
modified[InstanceEdit:166093] de Bono, B, 2005-08-17 10:29:13
[InstanceEdit:166099] de Bono, B, 2005-08-17 10:44:00
[InstanceEdit:166111] de Bono, B, 2005-08-18 13:45:59
[InstanceEdit:166840] de Bono, B, 2005-09-19 11:27:20
[InstanceEdit:168971] de Bono, B, 2005-11-22 19:37:29
[InstanceEdit:169764] de Bono, B, 2005-12-06 13:58:46
[InstanceEdit:169772] de Bono, B, 2005-12-06 15:36:07
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:181398] de Bono, B, 2006-06-09 10:18:34
[InstanceEdit:181963] de Bono, B, 2006-07-04 10:34:57
[InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15
[InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:937095] Shamovsky, V, 2010-08-25
[InstanceEdit:1013005] Shamovsky, V, 2010-11-11
[InstanceEdit:1018389] Shamovsky, V, 2010-11-16
[InstanceEdit:1095194] Shamovsky, V, 2010-11-30
[InstanceEdit:1564949] Shamovsky, V, 2011-09-06
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2428905] Shamovsky, V, 2012-08-08
[InstanceEdit:2586668] Shamovsky, V, 2012-11-16
[InstanceEdit:2603266] Shamovsky, V, 2012-11-19
[InstanceEdit:2627684] Shamovsky, V, 2012-11-19
[InstanceEdit:5621482] Shamovsky, V, 2014-08-29
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
output[Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:937065] Shamovsky, V, 2010-08-25
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359268] R-HSA-166091.3
summation[Summation:2586631] IRAK1 is recruited to the TLR complex through binding with I...
[Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
(hasEvent)[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(inferredFrom)[Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 [Gallus gallus]
(precedingEvent)[Reaction:166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal [Homo sapiens]
[Reaction:937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782066] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v59:[modifyText]
[_UpdateTracker:9788128] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v43:[addLiteratureReference, add_removeSummation]
[_UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference]
[_UpdateTracker:9789735] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v37:[modifyText]
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No pathways have been reviewed or authored by IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (166091)
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