Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person MyD88 forms a complex with TIRAP:activated TLR2/4
Class:Id Reaction:166072 _displayName MyD88 forms a complex with TIRAP:activated TLR2/4 _doRelease TRUE _timestamp 2018-08-09 02:30:26 authored [InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15 compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:166073] de Bono, B, 2005-08-16 16:18:41 edited [InstanceEdit:2562589] Shamovsky, V, 2012-11-06 input [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [Complex:2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] [Homo sapiens] literatureReference [LiteratureReference:165868] MyD88: an adapter that recruits IRAK to the IL-1 receptor complex [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:181352] Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 modified [InstanceEdit:166074] de Bono, B, 2005-08-16 16:19:41 [InstanceEdit:166077] de Bono, B, 2005-08-16 16:24:46 [InstanceEdit:166852] de Bono, B, 2005-09-21 09:42:25 [InstanceEdit:167909] Gillespie, ME, 2005-11-10 16:23:09 [InstanceEdit:168971] de Bono, B, 2005-11-22 19:37:29 [InstanceEdit:169750] de Bono, B, 2005-12-06 13:31:55 [InstanceEdit:169752] de Bono, B, 2005-12-06 13:38:05 [InstanceEdit:169755] de Bono, B, 2005-12-06 13:40:28 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:181353] de Bono, B, 2006-06-08 12:59:34 [InstanceEdit:181354] de Bono, B, 2006-06-08 13:03:55 [InstanceEdit:181358] de Bono, B, 2006-06-08 13:26:32 [InstanceEdit:181397] de Bono, B, 2006-06-09 10:16:08 [InstanceEdit:181963] de Bono, B, 2006-07-04 10:34:57 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:183118] de Bono, B, 2006-07-21 14:55:58 [InstanceEdit:188023] de Bono, B, 2006-09-29 15:51:19 [InstanceEdit:188061] de Bono, B, 2006-09-30 09:23:48 [InstanceEdit:188119] de Bono, B, 2006-09-30 13:45:09 [InstanceEdit:188150] de Bono, B, 2006-09-30 14:32:06 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:937102] Shamovsky, V, 2010-08-25 [InstanceEdit:1018388] Shamovsky, V, 2010-11-16 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:1564963] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201353] Shamovsky, V, 2012-04-19 [InstanceEdit:2299706] Shamovsky, V, 2012-06-01 [InstanceEdit:2603275] Shamovsky, V, 2012-11-19 [InstanceEdit:2627685] Shamovsky, V, 2012-11-19 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name MyD88 forms a complex with TIRAP:activated TLR2/4 output [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] [Homo sapiens] precedingEvent
regulatedBy [NegativeRegulation:188069] Negative regulation by 'SIGIRR [plasma membrane]' [NegativeRegulation:5432725] Negative regulation by 'SOCS1 [cytosol]' regulationReference [RegulationReference:9642398] Negative regulation by 'SIGIRR [plasma membrane]' Negative regulation of toll-like receptor-mediated immune responses [RegulationReference:9642671] Negative regulation by 'SOCS1 [cytosol]' Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation relatedSpecies [Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis releaseDate 2010-12-14 reviewed [InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:937065] Shamovsky, V, 2010-08-25 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:360249] R-HSA-166072.5 summation [Summation:169753] MyD88 binds to IRAK (IL-1 receptor-associated kinase) and th... (hasEvent) [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens] (inferredFrom) [Reaction:433961] Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 [Gallus gallus] (normalReaction) [FailedReaction:5602606] Defective MyD88 does not bind MAL(TIRAP):TLR2/4 [Homo sapiens] (precedingEvent) [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 [Homo sapiens] (replacementInstances) [_Deleted:744677] Deletion of instance: 166144 [_Deleted:744678] Deletion of instance: 166147 (updatedInstance) [_UpdateTracker:9786495] Update Tracker - [Reaction:166072] MyD88 forms a complex with TIRAP:activated TLR2/4 - v49:[addRegulator] [_UpdateTracker:9788538] Update Tracker - [Reaction:166072] MyD88 forms a complex with TIRAP:activated TLR2/4 - v41:[add_removeInput, removeSummation]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by MyD88 forms a complex with TIRAP:activated TLR2/4 (166072)
