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Details on Person Diagram of Regulation of cholesterol biosynthesis by SREBP (SREBF)

Class:IdPathwayDiagram:1660554
_displayNameDiagram of Regulation of cholesterol biosynthesis by SREBP (SREBF)
_timestamp2026-04-23 19:09:26
created[InstanceEdit:1660555] May, B, 2011-10-13
height781
modified[InstanceEdit:1660608] May, B, 2011-10-13
[InstanceEdit:2065546] May, B, 2012-01-23
[InstanceEdit:2065962] May, B, 2012-01-25
[InstanceEdit:2065976] May, B, 2012-01-25
[InstanceEdit:2110964] D'Eustachio, P, 2012-02-13
[InstanceEdit:2317533] May, B, 2012-06-13
[InstanceEdit:2317540] May, B, 2012-06-13
[InstanceEdit:2317553] May, B, 2012-06-13
[InstanceEdit:2326882] May, B, 2012-06-21
[InstanceEdit:2394004] May, B, 2012-06-28
[InstanceEdit:2413072] Wu, G, 2012-07-17
[InstanceEdit:2426170] May, B, 2012-07-27
[InstanceEdit:2426596] May, B, 2012-08-08
[InstanceEdit:2993479] May, B, 2013-01-19
[InstanceEdit:5260272] May, B, 2014-02-07
[InstanceEdit:9959903] D'Eustachio, Peter, 2025-07-02
[InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10
[InstanceEdit:9987663] D'Eustachio, Peter, 2026-04-23
representedPathway[Pathway:1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) [Homo sapiens]
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513 75 24" textPosition="798 514"> <Properties> <displayName>KPNB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="141" reactomeId="2317520" position="214 59" bounds="140 45 149 28" textPosition="152 51" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:SCAP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="143" reactomeId="193384" position="412 165" bounds="372 150 81 30" textPosition="392 154"> <Properties> <displayName>CHOL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.ProcessNode id="193" reactomeId="2426168" position="284 654" bounds="113 617 343 75" textPosition="140 639"> <Properties> <displayName>Activation of gene expression by SREBF (SREBP)</displayName> </Properties> </org.gk.render.ProcessNode> </Nodes> <Edges> <org.gk.render.RenderableReaction id="7" reactomeId="1655825" points="399 60, 506 62, 575 62" position="506 62" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="106" stoichiometry="4" points="372 90" /> <Input id="141" points="292 59" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Catalysts> <Catalyst id="141" points="292 52, 505 32" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2:SCAP binds CopII Coat Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="1655834" points="726 64, 766 64, 915 66" position="766 64" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="9" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Properties> <displayName>SREBP1A,1C,2:SCAP translocates to the Golgi</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="1655842" points="995 82, 996 127, 995 178" position="996 127" lineWidth="1.0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="13" stoichiometry="4" points="995 248" /> <Output id="14" points="1052 196" /> </Outputs> <Catalysts> <Catalyst id="15" points="1060 128" /> </Catalysts> <Properties> <displayName>S1P hydrolyzes SREBP1A,1C,2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16" reactomeId="1655851" points="995 287, 995 331, 996 408" position="995 331" lineWidth="1.0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Catalysts> <Catalyst id="18" points="1065 331" /> </Catalysts> <Properties> <displayName>S2P hydrolyzes SREBP1A,1C,2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="1655831" points="792 633, 773 633, 729 472, 581 470" position="729 472" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="72" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Properties> <displayName>SREBP1A,1C,2 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="2065549" points="997 451, 999 491, 999 513" position="999 491" lineWidth="1.0"> <Inputs> <Input id="17" stoichiometry="2" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Properties> <displayName>SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="2065550" points="901 554, 902 586, 902 620" position="902 586" lineWidth="1.0"> <Inputs> <Input id="139" points="854 540" /> <Input id="77" points="953 543" /> </Inputs> <Outputs> <Output id="72" /> </Outputs> <Catalysts> <Catalyst id="139" points="826 540, 849 585" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds Importin beta-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="2065539" points="560 523, 560 551, 562 577" position="560 551" lineWidth="1.0"> <Inputs> <Input id="81" points="615 513" /> <Input id="73" points="491 485" /> </Inputs> <Outputs> <Output id="83" points="591 605" /> <Output id="84" points="447 574" /> </Outputs> <Catalysts> <Catalyst id="81" points="659 521, 660 552" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2:Importin beta-1 dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="119" reactomeId="2317530" points="310 213, 351 259, 389 309" position="351 259" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="143" stoichiometry="4" points="380 183" /> <Input id="120" stoichiometry="4" points="384 215" /> <Input id="141" points="222 76" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Catalysts> <Catalyst id="141" points="220 76, 302 258" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="2317531" points="165 208, 152 250, 131 310" position="152 250" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="125" stoichiometry="4" points="106 141" /> <Input id="141" points="209 76" /> </Inputs> <Outputs> <Output id="126" /> </Outputs> <Catalysts> <Catalyst id="141" points="212 76, 196 250" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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