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Details on Person Transfer of LPS onto TLR4

Class:IdReaction:166041
_displayNameTransfer of LPS onto TLR4
_doReleaseTRUE
_timestamp2016-11-10 00:55:51
authored[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:166042] de Bono, B, 2005-08-16 13:31:58
edited[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input[Complex:166050] TLR4:LY96 [plasma membrane] [Homo sapiens]
[DefinedSet:166043] LPS:CD14 [extracellular region] [Homo sapiens]
[Complex:166050] TLR4:LY96 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:165842] MD-2: the Toll 'gatekeeper' in endotoxin signalling
[LiteratureReference:169767] LPS-binding proteins and receptors
[LiteratureReference:5467275] Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
[LiteratureReference:5467278] TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression
modified[InstanceEdit:166053] de Bono, B, 2005-08-16 13:42:10
[InstanceEdit:166090] de Bono, B, 2005-08-17 10:02:27
[InstanceEdit:166414] de Bono, B, 2005-08-30 11:59:13
[InstanceEdit:166851] de Bono, B, 2005-09-21 09:40:58
[InstanceEdit:168713] Gillespie, ME, 2005-11-17 05:55:10
[InstanceEdit:168953] de Bono, B, 2005-11-22 18:57:13
[InstanceEdit:169722] de Bono, B, 2005-12-06 10:14:20
[InstanceEdit:169771] de Bono, B, 2005-12-06 15:31:55
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:937118] Shamovsky, V, 2010-08-25
[InstanceEdit:1018390] Shamovsky, V, 2010-11-16
[InstanceEdit:1094899] Shamovsky, V, 2010-11-29
[InstanceEdit:1095195] Shamovsky, V, 2010-11-30
[InstanceEdit:1551953] Shamovsky, V, 2011-08-30
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2201361] Shamovsky, V, 2012-04-19
[InstanceEdit:2248863] Shamovsky, V, 2012-05-15
[InstanceEdit:2581523] Shamovsky, V, 2012-11-13
[InstanceEdit:5467282] Shamovsky, V, 2014-05-15
[InstanceEdit:8863994] Jupe, Steve, 2016-03-10
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTransfer of LPS onto TLR4
output[Complex:166850] TLR4:LY96:LPS:CD14 [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:166156] Negative regulation by 'RP105:MD1 [plasma membrane]'
[NegativeRegulation:5432892] Negative regulation by 'SFTPA oligomer, SFTPD oligomer [extracellular region]'
regulationReference[RegulationReference:9642837] Negative regulation by 'RP105:MD1 [plasma membrane]' Negative regulation of Toll-like receptor 4 signaling by the Toll-like
releaseDate2005-06-13
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358313] R-HSA-166041.6
summation[Summation:166415] The Toll-like receptor 4 (TLR4) is a membrane-spanning prote...
(hasEvent)[Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade [Homo sapiens]
(precedingEvent)[Reaction:2201293] Endocytosis of TLR4:LY96:LPS:CD14 [Homo sapiens]
[Reaction:2201316] Activated TLR2/4 interacts with MAL (TIRAP) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785117] Update Tracker - [Reaction:166041] Transfer of LPS onto TLR4 - v52:[modifyText]
[_UpdateTracker:9786574] Update Tracker - [Reaction:166041] Transfer of LPS onto TLR4 - v49:[addLiteratureReference, addRegulator]
[_UpdateTracker:9788648] Update Tracker - [Reaction:166041] Transfer of LPS onto TLR4 - v41:[removeOutput]
[_UpdateTracker:9790219] Update Tracker - [Reaction:166041] Transfer of LPS onto TLR4 - v34:[modifyText]
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