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Details on Person Phosphorylation of 4E-BP1 by activated mTORC1

Class:Id	Reaction:165692
_displayName	Phosphorylation of 4E-BP1 by activated mTORC1
_doRelease	TRUE
_timestamp	2026-03-05 18:49:08
authored	[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
catalystActivity	[CatalystActivity:165690] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:165688] de Bono, B, 2005-08-09 10:31:29
input	[Complex:72581] eIF4E:4E-BP [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9984236] Rothfels, Karen, 2026-01-23
literatureReference	[LiteratureReference:165687] Raptor, a binding partner of target of rapamycin (TOR), mediates TOR [LiteratureReference:165703] Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR
modified	[InstanceEdit:165723] de Bono, B, 2005-08-09 12:28:42 [InstanceEdit:165740] de Bono, B, 2005-08-09 12:57:03 [InstanceEdit:165759] de Bono, B, 2005-08-09 13:45:58 [InstanceEdit:165770] de Bono, B, 2005-08-09 14:47:39 [InstanceEdit:177919] Jassal, B, 2006-04-11 09:11:00 [InstanceEdit:3150160] Jupe, S, 2013-02-19 [InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05 [InstanceEdit:5686414] Jupe, Steve, 2015-04-01 [InstanceEdit:5687546] Jupe, Steve, 2015-04-08 [InstanceEdit:5687631] Jupe, Steve, 2015-04-08 [InstanceEdit:5693184] Jupe, Steve, 2015-05-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9690476] Jassal, Bijay, 2020-06-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29 [InstanceEdit:9982489] Orlic-Milacic, Marija, 2026-02-17 [InstanceEdit:9984238] Orlic-Milacic, Marija, 2026-03-05
name	Phosphorylation of 4E-BP1 by activated mTORC1
output	[SimpleEntity:29370] ADP [cytosol] [Complex:165697] eIF4E:4E-BP1-P [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:165680] Formation of active mTORC1 complex [Homo sapiens] [Reaction:165195] GTP loading by Rheb [Homo sapiens] [Reaction:5653968] Ragulator:Rag dimers:SLC38A9 bind mTORC1 [Homo sapiens] [Reaction:377186] Activated AKT phosphorylates AKT1S1 (PRAS40) [Homo sapiens] [Reaction:5672843] AKT1S1 (PRAS40) binds mTORC1 [Homo sapiens] [Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:5672902] Negative regulation by 'mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]' [NegativeRegulation:9690475] Negative regulation by 'FKBP1A:sirolimus [cytosol]'
regulationReference	[RegulationReference:9690474] Negative regulation by 'FKBP1A:sirolimus [cytosol]' Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
releaseDate	2005-04-11
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358617] R-HSA-165692.6
structureModified	[InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29
summation	[Summation:166184] Raptor recruits mTORC to non-phosphorylated 4E-BP1 bound to ...
(hasEvent)	[Pathway:166208] mTORC1-mediated signalling [Homo sapiens]
(precedingEvent)	[Reaction:165708] Dissociation of phosphorylated 4EBP1 from eIF4E [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776858] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v74:[addRegulator] [_UpdateTracker:9784626] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v53:[add_removeSummation] [_UpdateTracker:9785425] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v52:[addRegulator] [_UpdateTracker:9984727] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v96:[addRegulator, modifyText]
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