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Details on Person Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)

Class:Id	BlackBoxEvent:1655848
_displayName	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
_doRelease	TRUE
_timestamp	2026-04-13 17:17:30
authored	[InstanceEdit:1655770] May, B, 2011-09-28
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:1655841] May, B, 2011-10-13
edited	[InstanceEdit:1655770] May, B, 2011-09-28
goBiologicalProcess	[GO_BiologicalProcess:258336] gene expression
input	[EntityWithAccessionedSequence:2393972] HMGCS1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1660622] Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP [LiteratureReference:1655524] Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
modified	[InstanceEdit:1660648] May, B, 2011-10-14 [InstanceEdit:1989744] May, B, 2011-11-13 [InstanceEdit:2394002] May, B, 2012-06-28 [InstanceEdit:2426205] May, B, 2012-07-29 [InstanceEdit:2426206] May, B, 2012-07-30 [InstanceEdit:2426449] May, B, 2012-08-03 [InstanceEdit:2426556] May, B, 2012-08-04 [InstanceEdit:2426692] May, B, 2012-08-08 [InstanceEdit:2457633] May, B, 2012-08-25 [InstanceEdit:5649962] May, Bruce, 2014-11-24 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626994] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21 [InstanceEdit:9987322] D'Eustachio, Peter, 2026-04-13
name	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
output	[EntityWithAccessionedSequence:191329] HMGCS1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens] [Reaction:2426150] SREBP1A,1C,2 binds the HMGCS1 promoter [Homo sapiens] [Reaction:2065539] SREBP1A,1C,2:Importin beta-1 dissociates [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1989814] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:5649957] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641445] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis [RegulationReference:9642533] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm]' Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP
releaseDate	2011-12-06
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:2457630] Liang, Guosheng, 2012-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016305] R-HSA-1655848.6
summation	[Summation:1655818] The HMGCS1 gene is transcribed to yield mRNA and the mRNA is...
(hasEvent)	[Pathway:1989781] PPARA activates gene expression [Homo sapiens] [Pathway:2426168] Activation of gene expression by SREBF (SREBP) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784969] Update Tracker - [BlackBoxEvent:1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - v52:[addRegulator, add_removeInput] [_UpdateTracker:9786463] Update Tracker - [BlackBoxEvent:1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - v49:[removeRegulator] [_UpdateTracker:9788479] Update Tracker - [BlackBoxEvent:1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - v42:[addInput, add_removeRegulator]
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