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Details on Person Expression of Lanosterol Synthase (LSS)

Class:Id	BlackBoxEvent:1655828
_displayName	Expression of Lanosterol Synthase (LSS)
_doRelease	TRUE
_timestamp	2026-04-13 17:17:32
authored	[InstanceEdit:1655770] May, B, 2011-09-28
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1655841] May, B, 2011-10-13
edited	[InstanceEdit:1655770] May, B, 2011-09-28
goBiologicalProcess	[GO_BiologicalProcess:258336] gene expression
input	[EntityWithAccessionedSequence:2393967] LSS gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1660659] Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression
modified	[InstanceEdit:1660648] May, B, 2011-10-14 [InstanceEdit:2394002] May, B, 2012-06-28 [InstanceEdit:2426205] May, B, 2012-07-29 [InstanceEdit:2426206] May, B, 2012-07-30 [InstanceEdit:2426449] May, B, 2012-08-03 [InstanceEdit:2426556] May, B, 2012-08-04 [InstanceEdit:2426692] May, B, 2012-08-08 [InstanceEdit:2457633] May, B, 2012-08-25 [InstanceEdit:8963807] May, Bruce, 2017-02-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626995] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9961220] D'Eustachio, Peter, 2025-07-21 [InstanceEdit:9987322] D'Eustachio, Peter, 2026-04-13
name	Expression of Lanosterol Synthase (LSS)
output	[EntityWithAccessionedSequence:191371] LSS [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:2426154] SREBP1A,2 binds the LSS promoter [Homo sapiens] [Reaction:2065539] SREBP1A,1C,2:Importin beta-1 dissociates [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1655866] Positive gene expression regulation by 'SREBP1A,2:LSS gene [nucleoplasm]'
regulationReference	[RegulationReference:9641429] Positive gene expression regulation by 'SREBP1A,2:LSS gene [nucleoplasm]' Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis
releaseDate	2012-09-18
reviewed	[InstanceEdit:2457630] Liang, Guosheng, 2012-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464976] R-HSA-1655828.8
summation	[Summation:1655774] The LSS gene is transcribed to yield mRNA and the mRNA is tr... [Summation:1655783] SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of t...
(hasEvent)	[Pathway:2426168] Activation of gene expression by SREBF (SREBP) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775676] Update Tracker - [BlackBoxEvent:1655828] Expression of Lanosterol Synthase (LSS) - v78:[addSummation] [_UpdateTracker:9781882] Update Tracker - [BlackBoxEvent:1655828] Expression of Lanosterol Synthase (LSS) - v60:[add_removeInput]
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No pathways have been reviewed or authored by Expression of Lanosterol Synthase (LSS) (1655828)