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Details on Person SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm]

Class:Id	Complex:1655714
_displayName	SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm]
_timestamp	2014-02-07 16:48:02
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1655717] May, B, 2011-10-13
hasComponent	[Complex:381204] NF-Y [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381067] NFYB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:981546] NFYC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:420841] NFYA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2393984] TM7SF2 gene [nucleoplasm] [Homo sapiens] [Complex:1655744] SREBP1A,1C,2 dimer [nucleoplasm] [Homo sapiens] [DefinedSet:1655720] SREBF1A,1C,2 cleaved by S2P [nucleoplasm] [Homo sapiens] [DefinedSet:1655720] SREBF1A,1C,2 cleaved by S2P [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1655695] Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box [LiteratureReference:1655599] Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells [LiteratureReference:1655641] SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase [LiteratureReference:1655587] Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
modified	[InstanceEdit:2065546] May, B, 2012-01-23 [InstanceEdit:2065962] May, B, 2012-01-25 [InstanceEdit:2317551] May, B, 2012-06-13 [InstanceEdit:2393960] May, B, 2012-06-28 [InstanceEdit:2426142] May, B, 2012-07-27 [InstanceEdit:2426596] May, B, 2012-08-08 [InstanceEdit:5260272] May, B, 2014-02-07
name	SREBP1A,1C,2:NF-Y:TM7SF2 gene SREBF1A,1C,2:NF-Y:TM7SF2 gene
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2465567] R-HSA-1655714.1
(output)	[Reaction:2065966] SREBP1A,1C,2 binds the TM7SF2 promoter [Homo sapiens]
(regulator)	[PositiveGeneExpressionRegulation:1655859] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1655872] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9883208] Update Tracker - [Complex:1655714] SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] - v45:[updateContainedComponent] [_UpdateTracker:9888849] Update Tracker - [Complex:1655714] SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] - v48:[modifyName, updateContainedComponent]
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No pathways have been reviewed or authored by SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (1655714)