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Details on Person FMO1:FAD oxidizes HTAU to TAU

Class:Id	Reaction:1655453
_displayName	FMO1:FAD oxidizes HTAU to TAU
_doRelease	TRUE
_timestamp	2025-02-25 22:16:44
catalystActivity	[CatalystActivity:1655454] hypotaurine monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9816292] hypotaurine dehydrogenase activity of FMO1:FAD [endoplasmic reticulum membrane] Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1655458] Jassal, B, 2011-10-12
crossReference	[DatabaseIdentifier:9929921] RHEA:69820
input	[SimpleEntity:1655445] HTAU [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:9816289] Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine
modified	[InstanceEdit:1655880] Jassal, B, 2011-10-13 [InstanceEdit:1660488] Jassal, Bijay, 2011-10-13 [InstanceEdit:6814161] Jassal, Bijay, 2015-11-25 [InstanceEdit:6814162] Jassal, Bijay, 2015-11-25 [InstanceEdit:6814169] Jassal, Bijay, 2015-11-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9816288] D'Eustachio, Peter, 2022-09-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	FMO1:FAD oxidizes HTAU to TAU H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine Oxidation of hypotaurine to taurine
output	[SimpleEntity:159420] TAU [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:1655443] PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine [Homo sapiens] [Reaction:1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine [Homo sapiens] [Reaction:6814153] ADO oxidises 2AET to HTAU [Homo sapiens] [Reaction:6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9816294] D'Eustachio, Peter, 2022-09-02
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016548] R-HSA-1655453.6
structureModified	[InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29
summation	[Summation:1655459] FMO1:FAD (flavin monooxygenase 1 : FAD complex) catalyzes th...
(hasEvent)	[Pathway:1614558] Degradation of cysteine and homocysteine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846914] Update Tracker - [Reaction:1655453] FMO1:FAD oxidizes HTAU to TAU - v83:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by FMO1:FAD oxidizes HTAU to TAU (1655453)