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Details on Person PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine

Class:Id	Reaction:1655443
_displayName	PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine
_doRelease	TRUE
_timestamp	2025-02-25 22:17:15
authored	[InstanceEdit:1655432] Jassal, B, 2011-10-12
catalystActivity	[CatalystActivity:1655436] sulfinoalanine decarboxylase activity of PXKLP-K305-CSAD dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1655432] Jassal, B, 2011-10-12
crossReference	[DatabaseIdentifier:9925799] RHEA:16878
edited	[InstanceEdit:1655432] Jassal, B, 2011-10-12
inferredFrom	[Reaction:1655440] PXLP-K305-Csad decarboxylates 3-sulfinoalanine to hypotaurine [Rattus norvegicus]
input	[SimpleEntity:1614519] 3-Sulfinoalanine [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:1655437] Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties [LiteratureReference:9929923] Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression
modified	[InstanceEdit:1660488] Jassal, Bijay, 2011-10-13 [InstanceEdit:2272656] Jassal, B, 2012-05-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9644744] D'Eustachio, Peter, 2019-04-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine 3-sulfino-L-alanine + H(+) => CO2 + hypotaurine
output	[SimpleEntity:1655445] HTAU [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine [Homo sapiens] [Reaction:1614583] PXLP-K212-CTH cleaves L-Cystathionine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016386] R-HSA-1655443.5
structureModified	[InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29
summation	[Summation:1655442] Cysteine sulfinic acid decarboxylase (CSAD) mediates the dec...
(hasEvent)	[Pathway:1614558] Degradation of cysteine and homocysteine [Homo sapiens]
(precedingEvent)	[Reaction:1655453] FMO1:FAD oxidizes HTAU to TAU [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939707] Update Tracker - [Reaction:1655443] PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine - v92:[modifyText, removeInput, removeLiteratureReference]
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