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Details on Person Phosphorylation of complexed TSC2 by PKB

Class:IdReaction:165182
_displayNamePhosphorylation of complexed TSC2 by PKB
_doReleaseTRUE
_timestamp2026-03-09 13:48:38
authored[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
catalystActivity[CatalystActivity:9975699] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:165161] de Bono, B, 2005-08-01 10:10:30
input[SimpleEntity:113592] ATP [cytosol]
[Complex:165175] TSC1:TSC2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9982491] Rothfels, Karen, 2026-01-22
[InstanceEdit:9984240] Rothfels, Karen, 2026-03-05
literatureReference[LiteratureReference:532189] Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
modified[InstanceEdit:165660] de Bono, B, 2005-08-09 09:29:46
[InstanceEdit:165759] de Bono, B, 2005-08-09 13:45:58
[InstanceEdit:165769] de Bono, B, 2005-08-09 14:46:33
[InstanceEdit:166130] de Bono, B, 2005-08-18 14:29:18
[InstanceEdit:166202] de Bono, B, 2005-08-22 12:44:40
[InstanceEdit:177949] de Bono, B, 2006-04-11 13:14:30
[InstanceEdit:3150160] Jupe, S, 2013-02-19
[InstanceEdit:5687546] Jupe, Steve, 2015-04-08
[InstanceEdit:5687631] Jupe, Steve, 2015-04-08
[InstanceEdit:5693184] Jupe, Steve, 2015-05-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9982496] Orlic-Milacic, Marija, 2026-02-18
[InstanceEdit:9982867] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9984521] Orlic-Milacic, Marija, 2026-03-09
namePhosphorylation of complexed TSC2 by PKB
output[SimpleEntity:29370] ADP [cytosol]
[Complex:165180] TSC1:Inhibited TSC2-1-P [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2006-04-24
reviewed[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361721] R-HSA-165182.4
structureModified[InstanceEdit:9982867] Orlic-Milacic, Marija, 2026-02-19
summation[Summation:179051] Phosphorylation of TSC2 by AKT (PKB) disrupts TSC1:TSC2 hete...
(hasEvent)[Pathway:165181] Inhibition of TSC complex formation by AKT (PKB) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784835] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v53:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9911021] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v89:[modifyText]
[_UpdateTracker:9984595] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v96:[add_removeCatalystActivity, modifyText]
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