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Details on Person Phosphorylation of TSC2 by AKT (PKB)

Class:IdReaction:165162
_displayNamePhosphorylation of TSC2 by AKT (PKB)
_doReleaseTRUE
_timestamp2026-03-05 18:56:08
authored[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
catalystActivity[CatalystActivity:9975699] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:165161] de Bono, B, 2005-08-01 10:10:30
input[SimpleEntity:113592] ATP [cytosol]
[EntityWithAccessionedSequence:2980548] TSC2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9984240] Rothfels, Karen, 2026-03-05
literatureReference[LiteratureReference:165184] Upstream and downstream of mTOR
[LiteratureReference:199381] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
[LiteratureReference:9982857] Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes
[LiteratureReference:9982859] AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope
modified[InstanceEdit:165163] de Bono, B, 2005-08-01 11:31:37
[InstanceEdit:165201] de Bono, B, 2005-08-02 15:13:36
[InstanceEdit:165659] de Bono, B, 2005-08-09 09:29:33
[InstanceEdit:165759] de Bono, B, 2005-08-09 13:45:58
[InstanceEdit:165769] de Bono, B, 2005-08-09 14:46:33
[InstanceEdit:166131] de Bono, B, 2005-08-18 14:30:20
[InstanceEdit:166201] de Bono, B, 2005-08-22 12:38:14
[InstanceEdit:177949] de Bono, B, 2006-04-11 13:14:30
[InstanceEdit:2980545] Jassal, B, 2013-01-11
[InstanceEdit:2997527] Jassal, B, 2013-01-23
[InstanceEdit:3150160] Jupe, S, 2013-02-19
[InstanceEdit:5687546] Jupe, Steve, 2015-04-08
[InstanceEdit:5687631] Jupe, Steve, 2015-04-08
[InstanceEdit:5693184] Jupe, Steve, 2015-05-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9982865] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9982867] Orlic-Milacic, Marija, 2026-02-19
[InstanceEdit:9984241] Orlic-Milacic, Marija, 2026-03-05
namePhosphorylation of TSC2 by AKT (PKB)
output[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:165164] p-S939,S1130,T1462-TSC2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2006-04-24
reviewed[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359577] R-HSA-165162.4
structureModified[InstanceEdit:9982865] Orlic-Milacic, Marija, 2026-02-19
summation[Summation:179081] AKT (PKB) phosphorylates TSC2 decreasing its activity and di...
(hasEvent)[Pathway:165181] Inhibition of TSC complex formation by AKT (PKB) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784600] Update Tracker - [Reaction:165162] Phosphorylation of TSC2 by PKB - v53:[modifyText]
[_UpdateTracker:9787609] Update Tracker - [Reaction:165162] Phosphorylation of TSC2 by PKB - v44:[add_removeInput]
[_UpdateTracker:9984704] Update Tracker - [Reaction:165162] Phosphorylation of TSC2 by AKT (PKB) - v96:[add_removeCatalystActivity, modifyText, removeLiteratureReference]
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