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Details on Person Nef mediated activation of the T-cell receptor

Class:Id	Reaction:164943
_displayName	Nef mediated activation of the T-cell receptor
_doRelease	TRUE
_timestamp	2025-06-03 18:47:00
authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:164942] Gillespie, ME, 2005-07-22 21:04:05
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
input	[EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] [Human immunodeficiency virus 1] [OtherEntity:167540] Lipid Raft [cytosol] [EntityWithAccessionedSequence:164946] PAK2(1-524) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:198166] CD247-1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:182142] Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex [LiteratureReference:182200] The Nef protein of HIV-1 associates with rafts and primes T cells for activation [LiteratureReference:200923] Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation [LiteratureReference:200926] CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable [LiteratureReference:200924] Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX [LiteratureReference:200959] Identification of the Nef-associated kinase as p21-activated kinase 2 [LiteratureReference:200940] Lentivirus Nef specifically activates Pak2
modified	[InstanceEdit:167619] Gillespie, ME, 2005-10-20 18:11:54 [InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:170617] Gopinathrao, G, 2006-01-08 02:23:40 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:182233] Gillespie, ME, 2006-07-06 19:50:31 [InstanceEdit:182300] Gillespie, ME, 2006-07-06 21:32:56 [InstanceEdit:182408] Gillespie, ME, 2006-07-07 16:33:16 [InstanceEdit:182793] Gillespie, ME, 2006-07-18 19:30:59 [InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36 [InstanceEdit:200907] Gillespie, ME, 2007-07-25 21:01:05 [InstanceEdit:200960] Gillespie, ME, 2007-07-26 04:52:04 [InstanceEdit:201389] Gillespie, ME, 2007-08-07 14:42:02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2980520] Jupe, S, 2013-01-11 [InstanceEdit:3076315] Gillespie, ME, 2013-02-06 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:5656435] Gillespie, Marc E, 2014-12-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9773553] Weiser, Joel, 2022-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9953471] Shamovsky, Veronica, 2025-06-02 [InstanceEdit:9953542] Gillespie, Marc E, 2025-06-03
name	Nef mediated activation of the T-cell receptor
output	[Complex:167576] Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-09-04
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359076] R-HSA-164943.5
summation	[Summation:182201] Nef drives the formation of lipid raft complexes.
(hasEvent)	[Pathway:164944] Nef and signal transduction [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787549] Update Tracker - [Reaction:164943] Nef mediated activation of the T-cell receptor - v44:[add_removeInput]
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No pathways have been reviewed or authored by Nef mediated activation of the T-cell receptor (164943)