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Details on Person UniProt:Q95V55 foxo
Class:Id
ReferenceGeneProduct:164749
_chainChangeLog
chain:1-613 added on Sat February 7 2015
_displayName
UniProt:Q95V55 foxo
_timestamp
2023-11-03 17:59:53
chain
chain:1-613
checksum
B472822ACA169BF9
comment
FUNCTION Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.SUBUNIT Interacts with melt.INTERACTION When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.ALTERNATIVE PRODUCTS Mutant foxo lacking Akt1 phosphorylation sites no longer responds to insulin inhibition, remains in the nucleus, and is constitutively active, inducing cell arrest.
