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Details on Person Biogenesis and assembly of the telomerase RNP

Class:Id	Reaction:164616
_displayName	Biogenesis and assembly of the telomerase RNP
_doRelease	TRUE
_timestamp	2020-05-04 11:55:06
authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:164613] Gillespie, ME, 2005-06-03 18:18:21
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00 [InstanceEdit:9667984] Orlic-Milacic, Marija, 2019-11-18 [InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
figure	[Figure:176730] /figures/telomeraseassembly.jpg
goBiologicalProcess	[GO_BiologicalProcess:18229] telomere maintenance via telomerase
input	[EntityWithAccessionedSequence:163077] Telomerase RNA Component (TERC) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:163076] TERT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:163102] DKC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:163102] DKC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:418386] WRAP53 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:418325] NHP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:418325] NHP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6790665] NOP10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6790665] NOP10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6790707] GAR1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6790707] GAR1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:177185] Cell cycle-regulated trafficking of human telomerase to telomeres [LiteratureReference:163113] Functional conservation of the telomerase protein Est1p in humans [LiteratureReference:417089] Protein composition of catalytically active human telomerase from immortal cells [LiteratureReference:417080] Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly [LiteratureReference:418255] Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita [LiteratureReference:418381] A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis [LiteratureReference:9667990] Cryo-EM structure of substrate-bound human telomerase holoenzyme
modified	[InstanceEdit:164690] Gillespie, ME, 2005-06-14 19:41:12 [InstanceEdit:176720] Gillespie, ME, 2006-03-09 16:26:41 [InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16 [InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21 [InstanceEdit:177238] Gillespie, ME, 2006-03-24 04:35:12 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177809] Gillespie, ME, 2006-04-07 03:52:02 [InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41 [InstanceEdit:180778] Gillespie, ME, 2006-06-05 03:42:53 [InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53 [InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39 [InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36 [InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25 [InstanceEdit:418317] D'Eustachio, P, 2009-04-21 14:09:44 [InstanceEdit:418383] D'Eustachio, P, 2009-04-22 14:14:01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9667992] Orlic-Milacic, Marija, 2019-11-18 [InstanceEdit:9668145] Orlic-Milacic, Marija, 2019-11-19 [InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9686485] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9686487] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Biogenesis and assembly of the telomerase RNP TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP
output	[Complex:163101] Telomerase RNP [nucleoplasm] [Homo sapiens]
regulatedBy	[PositiveRegulation:418320] Positive regulation by 'RUVBL1 [nucleoplasm]' [PositiveRegulation:418324] Positive regulation by 'RUVBL2 [nucleoplasm]'
regulationReference	[RegulationReference:9642472] Positive regulation by 'RUVBL1 [nucleoplasm]' Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly [RegulationReference:9642589] Positive regulation by 'RUVBL2 [nucleoplasm]' Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
releaseDate	2006-08-02
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9667984] Orlic-Milacic, Marija, 2019-11-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358297] R-HSA-164616.7
summation	[Summation:164681] hTERC is transcribed as a precursor and is processed at its ...
(hasEvent)	[Pathway:171319] Telomere Extension By Telomerase [Homo sapiens]
(precedingEvent)	[Reaction:163096] Recruitment of Telomerase RNP to the Telomeric Chromosome End [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776988] Update Tracker - [Reaction:164616] Biogenesis and assembly of the telomerase RNP - v73:[modifyText, removeLiteratureReference] [_UpdateTracker:9777080] Update Tracker - [Reaction:164616] Biogenesis and assembly of the telomerase RNP - v72:[addInput, addLiteratureReference, modifyText, removeRegulator] [_UpdateTracker:9791538] Update Tracker - [Reaction:164616] Biogenesis and assembly of the telomerase RNP - v29:[addLiteratureReference, addRegulator, add_removeInput, modifyText]
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