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Details on Person Guanine nucleotide binding proteins or G proteins constitute...
| Class:Id | Summation:164353 |
|---|---|
| _displayName | Guanine nucleotide binding proteins or G proteins constitute... |
| _timestamp | 2005-07-26 19:03:36 |
| created | [InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39 |
| literatureReference | [LiteratureReference:164382] Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting [LiteratureReference:164362] Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits [LiteratureReference:164373] Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning |
| modified | [InstanceEdit:164392] Gopinathrao, G, D'Eustachio, P, 2005-05-19 14:01:43 [InstanceEdit:164567] D'Eustachio, P, 2005-05-26 21:10:03 [InstanceEdit:164961] D'Eustachio, P, 2005-07-26 19:02:19 |
| text | Guanine nucleotide binding proteins or G proteins constitute a large family of proteins that transmit signals from membrane receptors to downstream effector molecules. Each G protein is composed of 3 subunits: alpha, beta and gamma. The alpha subunit binds to guanine nucleotide and is important for receptor coupling and effector activation. Each of s, i and q - forms of the alpha subunit has a functional specificity. About 4 isoforms of the beta subunit are known. Of the 12 subunits of gamma subunits known so far, subunits 1 and 9 are active in photoreceptor coupled signalling while others are expressed in various tissues. The beta and gamma subunits occur as dimers on the cell surface and the specific role, tissue occurrence and the binding preferences between isoforms of these subunits are still being unraveled (Ray et al.,1995; Cali et al.,1992). |
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