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Details on Person LKB1 phosphorylates the alpha subunit of AMPK heterotrimer

Class:Id	Reaction:164151
_displayName	LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
_doRelease	TRUE
_timestamp	2024-02-12 20:42:48
authored	[InstanceEdit:164203] Gopinathrao, G, 2005-05-12 21:32:40
catalystActivity	[CatalystActivity:164052] protein serine/threonine kinase activity of STK11 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:164169] Gopinathrao, G, 2005-05-11 18:49:22
crossReference	[DatabaseIdentifier:9857129] RHEA:46609
inferredFrom	[Reaction:164106] rLkb-1 (Stk-11) activates AMPK by phosphorylation [Rattus norvegicus]
input	[Complex:163747] AMPK heterotrimer:AMP [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
modified	[InstanceEdit:164203] Gopinathrao, G, 2005-05-12 21:32:40 [InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39 [InstanceEdit:165156] Gopinathrao, G, 2005-07-29 21:00:28 [InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59 [InstanceEdit:660249] D'Eustachio, P, 2010-04-30 [InstanceEdit:2660809] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
output	[Complex:163736] Activated AMPK heterotrimer [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm]
precedingEvent	[Reaction:163664] AMP binds to gamma subunit of AMP kinase heterotrimer [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-04-11
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361138] R-HSA-164151.4
structureModified	[InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02
summation	[Summation:164214] LKB1 phosphorylates threonine residue 172 of the alpha subun...
(hasEvent)	[Pathway:163680] AMPK inhibits chREBP transcriptional activation activity [Homo sapiens]
(precedingEvent)	[Reaction:163691] Phosphorylation of ChREBP at Serine 556 by AMPK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790708] Update Tracker - [Reaction:164151] LKB1 phosphorylates the alpha subunit of AMPK heterotrimer - v33:[addInput, addOutput] [_UpdateTracker:9864208] Update Tracker - [Reaction:164151] LKB1 phosphorylates the alpha subunit of AMPK heterotrimer - v88:[addOutput]
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