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Details on Person A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
| Class:Id | LiteratureReference:163904 |
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| _displayName | A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain |
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| _timestamp | 2005-05-10 08:47:47 |
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| author | [Person:163902] De Strooper, B
[Person:163906] Annaert, W
[Person:163899] Cupers, P
[Person:163909] Saftig, P
[Person:163910] Craessaerts, K
[Person:157347] Mumm, JS
[Person:157931] Schroeter, EH
[Person:163913] Schrijvers, V
[Person:157788] Wolfe, MS
[Person:157328] Ray, WJ
[Person:163914] Goate, A
[Person:157071] Kopan, R |
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| created | [InstanceEdit:163908] Jassal, B, 2005-05-10 08:47:41 |
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| journal | Nature |
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| pages | 518-22 |
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| pubMedIdentifier | 10206645 |
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| title | A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain |
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| volume | 398 |
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| year | 1999 |
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| (literatureReference) | [Reaction:157353] NEXT1 is cleaved to produce NICD1 [Homo sapiens]
[Reaction:157640] NEXT2 is cleaved to produce NICD2 [Homo sapiens]
[Reaction:209285] The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm [Mus musculus]
[Pathway:1980143] Signaling by NOTCH1 [Homo sapiens]
[Pathway:1980145] Signaling by NOTCH2 [Homo sapiens]
[Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus [Homo sapiens]
[Reaction:2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants [Homo sapiens]
[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
[Reaction:9980918] Gamma-secretase cleaves NEXT1 yielding NICD1 [Homo sapiens]
[Summation:9980216] Based on a mouse model system, ligand-mediated activation... |
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No pathways have been reviewed or authored by A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain (163904)
