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Details on Person HEXA cleaves the terminal GlcNAc from keratan sulfate

Class:Id	Reaction:1638053
_displayName	HEXA cleaves the terminal GlcNAc from keratan sulfate
_doRelease	TRUE
_timestamp	2025-03-14 09:03:49
authored	[InstanceEdit:1630307] Jassal, B, 2011-10-05
catalystActivity	[CatalystActivity:1605773] beta-N-acetylhexosaminidase activity of bHEXA [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1638039] Jassal, B, 2011-10-06
edited	[InstanceEdit:1630307] Jassal, B, 2011-10-05
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [SimpleEntity:2105012] GlcNAc-Gal-GlcNAc(S)-Gal [lysosomal lumen]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:1605770] Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase
modified	[InstanceEdit:1638075] Jassal, B, 2011-10-07 [InstanceEdit:1638090] Jassal, B, 2011-10-07 [InstanceEdit:1793216] Jassal, B, 2011-10-21 [InstanceEdit:2022912] Jassal, B, 2011-12-01 [InstanceEdit:2105013] Jassal, B, 2012-02-09 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2457639] Jassal, B, 2012-08-27 [InstanceEdit:3656262] Jassal, B, 2013-05-31 [InstanceEdit:3662342] Jassal, B, 2013-06-07 [InstanceEdit:9638080] Jassal, Bijay, 2019-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12 [InstanceEdit:9942322] Stephan, Ralf, 2025-03-14
name	HEXA cleaves the terminal GlcNAc from keratan sulfate
output	[SimpleEntity:2105010] Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:1678743] GlcNAc [lysosomal lumen]
precedingEvent	[Reaction:1638032] GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate [Homo sapiens] [Reaction:1630306] GLB1 hydrolyses a glycosaminoglycan [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294872] R-HSA-1638053.4
structureModified	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation	[Summation:1638038] Beta-hexosaminidase (HEX) cleaves the terminal N-acetyl gluc...
(hasEvent)	[Pathway:2022857] Keratan sulfate degradation [Homo sapiens]
(normalReaction)	[FailedReaction:9035978] Defective HEXA does not cleave the terminal GalNAc from keratan sulfate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786960] Update Tracker - [Reaction:1638053] HEXA cleaves the terminal GalNAc from keratan sulfate - v46:[modifyText, removeLiteratureReference] [_UpdateTracker:9953719] Update Tracker - [Reaction:1638053] HEXA cleaves the terminal GlcNAc from keratan sulfate - v93:[add_removeOutput, modifyText]
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