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Details on Person Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome

Class:Id	LiteratureReference:1637873
_displayName	Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
_timestamp	2011-10-05 18:32:32
author	[Person:1602218] Chase, A [Person:1604774] Grand, FH [Person:1602219] Cross, NC
created	[InstanceEdit:1637874] Rothfels, K, 2011-10-05
journal	Blood
pages	3729-34
pubMedIdentifier	17698633
title	Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
volume	110
year	2007
(literatureReference)	[DefinedSet:2045079] Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol] [Reaction:1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation [Homo sapiens] [Reaction:1839065] Phosphorylation of cytosolic FGFR1 fusion dimers [Homo sapiens] [Reaction:1839094] Activated FGFR1 mutants and fusions bind PLCG1 [Homo sapiens] [Reaction:1839112] Phosphorylation of STAT5 by cytosolic FGFR1 fusions [Homo sapiens] [Pathway:1839117] Signaling by cytosolic FGFR1 fusion mutants [Homo sapiens]
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No pathways have been reviewed or authored by Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome (1637873)