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Details on Person Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

Class:IdBlackBoxEvent:163770
_displayNameTranscriptional activation of Citrate lyase monomer gene by ChREBP:MLX
_doReleaseTRUE
_timestamp2026-03-26 18:44:56
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
goBiologicalProcess[GO_BiologicalProcess:258336] gene expression
input[EntityWithAccessionedSequence:9666703] ACLY gene [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
[LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
[LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
modified[InstanceEdit:163775] Gopinathrao, G, 2005-05-06 17:25:24
[InstanceEdit:164169] Gopinathrao, G, 2005-05-11 18:49:22
[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
[InstanceEdit:164392] Gopinathrao, G, D'Eustachio, P, 2005-05-19 14:01:43
[InstanceEdit:164422] Gopinathrao, G, 2005-05-19 18:05:19
[InstanceEdit:164424] Gopinathrao, G, 2005-05-19 19:11:43
[InstanceEdit:165156] Gopinathrao, G, 2005-07-29 21:00:28
[InstanceEdit:166649] Wu, G, 2005-09-10 18:16:19
[InstanceEdit:166846] Schmidt, EE, 2005-09-21 09:32:23
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
[InstanceEdit:201397] Gopinathrao, G, 2007-08-07 15:48:50
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:2671770] D'Eustachio, P, 2012-11-25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984961] Duenas, Corina, 2017-04-11
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9644853] Jassal, Bijay, 2019-04-25
[InstanceEdit:9666704] Jassal, Bijay, 2019-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
[InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05
[InstanceEdit:9985777] D'Eustachio, Peter, 2026-03-26
nameTranscriptional activation of Citrate lyase monomer gene by ChREBP:MLX
output[Complex:76188] ACLY tetramer [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:164421] Positive gene expression regulation by 'MLXIPL:MLX:ACLY gene [nucleoplasm]'
regulationReference[RegulationReference:9857473] Positive gene expression regulation by 'MLXIPL:MLX:ACLY gene [nucleoplasm]' Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
releaseDate2005-04-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360708] R-HSA-163770.8
summation[Summation:179357] The ACLY (ATP citrate synthase) gene, activated by binding o...
(hasEvent)[Pathway:163765] ChREBP activates metabolic gene expression [Homo sapiens]
(precedingEvent)[Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777422] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v71:[addInput]
[_UpdateTracker:9777805] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v69:[add_removeOutput]
[_UpdateTracker:9781421] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v61:[addLiteratureReference]
[_UpdateTracker:9790470] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v33:[add_removeRegulator]
[_UpdateTracker:9864145] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v88:[addLiteratureReference, add_removeRegulator, modifyText]
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