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Details on Person Formation of fatty acid synthase (FAS) dimer

Class:Id	Reaction:163756
_displayName	Formation of fatty acid synthase (FAS) dimer
_doRelease	TRUE
_timestamp	2024-04-12 19:41:44
catalystActivity	[CatalystActivity:9865848] fatty acid synthase activity of FASN [cytosol]
catalystActivityReference	[CatalystActivityReference:9865849] fatty acid synthase activity of FASN [cytosol] Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
input	[EntityWithAccessionedSequence:54659] FASN [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:54659] FASN [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
literatureReference	[LiteratureReference:539096] Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
modified	[InstanceEdit:166649] Wu, G, 2005-09-10 18:16:19 [InstanceEdit:166846] Schmidt, EE, 2005-09-21 09:32:23 [InstanceEdit:188678] Gopinathrao, G, 2006-10-20 19:25:59 [InstanceEdit:539120] D'Eustachio, P, 2010-03-09 [InstanceEdit:3150161] D'Eustachio, P, 2013-02-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19 [InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12 [InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
name	Formation of fatty acid synthase (FAS) dimer
output	[Complex:77380] FASN dimer [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:163733] Transcriptional activation of FASN monomer gene by ChREBP:MLX [Homo sapiens] [Reaction:9856546] MLXIPL:MLX binds FASN gene promoter [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2005-09-26
reviewed	[InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360184] R-HSA-163756.4
structureModified	[InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19
summation	[Summation:178786] Association of cytosolic FAS into multimers is linked to inc...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate [Homo sapiens] [Reaction:9948053] NS3 binds FASN dimer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790710] Update Tracker - [Reaction:163756] Formation of fatty acid synthase (FAS) dimer - v33:[addLiteratureReference, modifyText] [_UpdateTracker:9911048] Update Tracker - [Reaction:163756] Formation of fatty acid synthase (FAS) dimer - v89:[addCatalystActivity]
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