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Details on Person D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate

Class:Id	Reaction:163741
_displayName	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
_doRelease	TRUE
_timestamp	2025-01-06 09:06:35
catalystActivity	[CatalystActivity:71323] transketolase activity of TKT dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643773] transketolase activity of TKT dimer [cytosol] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
crossReference	[DatabaseIdentifier:9934066] RHEA:10509
input	[SimpleEntity:29578] GA3P [cytosol] [SimpleEntity:29882] SH7P [cytosol]
literatureReference	[LiteratureReference:199810] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
modified	[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39 [InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59 [InstanceEdit:179507] D'Eustachio, P, 2006-05-05 15:53:26 [InstanceEdit:199798] D'Eustachio, P, 2007-07-12 14:26:41 [InstanceEdit:469645] D'Eustachio, P, 2010-01-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9934059] Stephan, Ralf, 2025-01-06 [InstanceEdit:9934068] Stephan, Ralf, 2025-01-06
name	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate TKT dimer transfers two-carbon ketol group onto GA3P
output	[SimpleEntity:73578] R5P [cytosol] [SimpleEntity:29790] XY5P [cytosol]
precedingEvent	[Reaction:70454] TPI1 dimer isomerizes DHAP to GA3P [Homo sapiens] [Reaction:71496] Aldolase tetramer cleaves F1,6PP [Homo sapiens] [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP [Homo sapiens] [Reaction:163764] D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate [Homo sapiens] [Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens]
releaseDate	2005-09-26
reverseReaction	[Reaction:71324] ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate [Homo sapiens] [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360561] R-HSA-163741.5
summation	[Summation:178634] Cytosolic transketolase (TKT) catalyzes the reversible react...
(hasEvent)	[Pathway:71336] Pentose phosphate pathway [Homo sapiens] [Pathway:163754] Insulin effects increased synthesis of Xylulose-5-Phosphate [Homo sapiens]
(reverseReaction)	[Reaction:71324] ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781228] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v61:[modifyText] [_UpdateTracker:9791027] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v32:[modifyText] [_UpdateTracker:9792271] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v22:[addLiteratureReference] [_UpdateTracker:9864189] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v88:[modifyText]
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