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Details on Person Transcriptional activation of FASN monomer gene by ChREBP:MLX

Class:IdBlackBoxEvent:163733
_displayNameTranscriptional activation of FASN monomer gene by ChREBP:MLX
_doReleaseTRUE
_timestamp2026-03-26 18:44:58
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
goBiologicalProcess[GO_BiologicalProcess:258336] gene expression
input[EntityWithAccessionedSequence:2393979] FASN gene [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
[LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
[LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
modified[InstanceEdit:163775] Gopinathrao, G, 2005-05-06 17:25:24
[InstanceEdit:164169] Gopinathrao, G, 2005-05-11 18:49:22
[InstanceEdit:164236] Gopinathrao, G, 2005-05-13 00:50:35
[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
[InstanceEdit:164392] Gopinathrao, G, D'Eustachio, P, 2005-05-19 14:01:43
[InstanceEdit:164422] Gopinathrao, G, 2005-05-19 18:05:19
[InstanceEdit:164424] Gopinathrao, G, 2005-05-19 19:11:43
[InstanceEdit:165156] Gopinathrao, G, 2005-07-29 21:00:28
[InstanceEdit:166649] Wu, G, 2005-09-10 18:16:19
[InstanceEdit:166672] Gopinathrao, G, 2005-09-14 21:04:36
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
[InstanceEdit:201397] Gopinathrao, G, 2007-08-07 15:48:50
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:2671770] D'Eustachio, P, 2012-11-25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984883] Duenas, Corina, 2017-04-11
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
[InstanceEdit:9857282] D'Eustachio, Peter, 2024-01-03
[InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05
[InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
[InstanceEdit:9985777] D'Eustachio, Peter, 2026-03-26
nameTranscriptional activation of FASN monomer gene by ChREBP:MLX
output[EntityWithAccessionedSequence:54659] FASN [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[PositiveGeneExpressionRegulation:164420] Positive gene expression regulation by 'MLXIPL:MLX:FASN gene [nucleoplasm]'
regulationReference[RegulationReference:9857482] Positive gene expression regulation by 'MLXIPL:MLX:FASN gene [nucleoplasm]' Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
releaseDate2005-09-26
reviewed[InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361907] R-HSA-163733.6
structureModified[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
summation[Summation:179358] The ACLY (ATP citrate synthase) gene, activated by binding o...
(hasEvent)[Pathway:163765] ChREBP activates metabolic gene expression [Homo sapiens]
(precedingEvent)[Reaction:163756] Formation of fatty acid synthase (FAS) dimer [Homo sapiens]
[Reaction:199202] Phosphopantetheine conjugation of the ACP domain of FAS [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780976] Update Tracker - [BlackBoxEvent:163733] Transcriptional activation of FAS monomer gene by ChREBP:MLX - v61:[addLiteratureReference, modifyText]
[_UpdateTracker:9790572] Update Tracker - [BlackBoxEvent:163733] Transcriptional activation of FAS monomer gene by ChREBP:MLX - v33:[add_removeRegulator]
[_UpdateTracker:9864093] Update Tracker - [BlackBoxEvent:163733] Transcriptional activation of FASN monomer gene by ChREBP:MLX - v88:[addInput, add_removeLiteratureReference, add_removeRegulator, modifyText]
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