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Details on Person PP2A complex dephosphorylates pChREBP (MLXIPL)

Class:IdReaction:163689
_displayNamePP2A complex dephosphorylates pChREBP (MLXIPL)
_doReleaseTRUE
_timestamp2025-06-02 14:56:49
catalystActivity[CatalystActivity:163684] protein serine/threonine phosphatase activity of PP2A-ABdeltaC complex [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:163686] Gopinathrao, G, 2005-05-04 21:08:21
crossReference[DatabaseIdentifier:9857130] RHEA:20630
inferredFrom
input[EntityWithAccessionedSequence:164351] p-S196,T653-MLXIPL [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9949601] D'Eustachio, Peter, 2025-05-22
literatureReference[LiteratureReference:164225] A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
modified[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
[InstanceEdit:164169] Gopinathrao, G, 2005-05-11 18:49:22
[InstanceEdit:164238] Gopinathrao, G, 2005-05-13 01:40:30
[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
[InstanceEdit:165156] Gopinathrao, G, 2005-07-29 21:00:28
[InstanceEdit:166649] Wu, G, 2005-09-10 18:16:19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02
[InstanceEdit:9949564] D'Eustachio, Peter, 2025-05-22
[InstanceEdit:9949600] D'Eustachio, Peter, 2025-05-22
[InstanceEdit:9953426] D'Eustachio, Peter, 2025-06-02
namePP2A complex dephosphorylates pChREBP (MLXIPL)
O-phospho-L-seryl-(protein) + H2O = L-seryl-(protein) + phosphate
output[EntityWithAccessionedSequence:164365] p-T653-MLXIPL [cytosol] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[PositiveRegulation:166240] Positive regulation by 'XY5P [cytosol]'
releaseDate2005-09-26
reviewed[InstanceEdit:9953425] Hill, David P, 2025-06-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360268] R-HSA-163689.5
structureModified[InstanceEdit:9949564] D'Eustachio, Peter, 2025-05-22
summation[Summation:178658] Cytosolic PP2A-ABdeltaC complex, activated by xylulose 5-pho...
(hasEvent)[Pathway:163767] PP2A-mediated dephosphorylation of key metabolic factors [Homo sapiens]
(precedingEvent)[BlackBoxEvent:163670] Nuclear transport of pChREBP (Thr 666) protein [Homo sapiens]
(replacementInstances)[_Deleted:9949566] Deletion of instance: 163769
(updatedInstance)[_UpdateTracker:9846645] Update Tracker - [Reaction:163689] Dephosphorylation of pChREBP (Ser 196) by PP2A - v84:[modifyText]
[_UpdateTracker:9864255] Update Tracker - [Reaction:163689] Dephosphorylation of pChREBP (Ser 196) by PP2A - v88:[modifyText]
[_UpdateTracker:9953547] Update Tracker - [Reaction:163689] PP2A complex dephosphorylates pChREBP (MLXIPL) - v93:[modifyText, removeLiteratureReference, removeRegulator]
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