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Details on Person Glucagon binds to Glucagon receptor

Class:Id	Reaction:163625
_displayName	Glucagon binds to Glucagon receptor
_doRelease	TRUE
_timestamp	2025-05-28 14:32:02
authored	[InstanceEdit:163620] Gopinathrao, G, 2005-05-03 20:30:53
catalystActivity	[CatalystActivity:9857011] glucagon receptor activity of GCGR [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:163620] Gopinathrao, G, 2005-05-03 20:30:53
edited	[InstanceEdit:420077] Jassal, Bijay, 2009-05-11
input	[EntityWithAccessionedSequence:163626] GCG(53-81) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9820623] GCGR [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9953062] D'Eustachio, Peter, 2025-05-28
literatureReference	[LiteratureReference:164049] Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma [LiteratureReference:164180] Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists [LiteratureReference:420120] The amino acid sequence of human glucagon [LiteratureReference:420150] The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization
modified	[InstanceEdit:164169] Gopinathrao, G, 2005-05-11 18:49:22 [InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39 [InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59 [InstanceEdit:420077] Jassal, Bijay, 2009-05-11 [InstanceEdit:420852] Jassal, Bijay, 2009-05-14 [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:422124] Jassal, Bijay, 2009-05-26 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9820626] D'Eustachio, Peter, 2022-11-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857012] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9860024] D'Eustachio, Peter, 2024-01-29 [InstanceEdit:9953059] D'Eustachio, Peter, 2025-05-28 [InstanceEdit:9953060] D'Eustachio, Peter, 2025-05-28
name	Glucagon binds to Glucagon receptor
output	[Complex:163627] GCGR:GCG(53-81) [plasma membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22 [InstanceEdit:9860019] D'Eustachio, Peter, 2024-01-29 [InstanceEdit:9953061] Hill, David P, 2025-05-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362067] R-HSA-163625.5
structureModified	[InstanceEdit:9857012] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9953059] D'Eustachio, Peter, 2025-05-28
summation	[Summation:420110] Glucagon (Thomsen J et al, 1972) is an important peptide hor...
(hasEvent)	[Pathway:163359] Glucagon signaling in metabolic regulation [Homo sapiens] [Pathway:420092] Glucagon-type ligand receptors [Homo sapiens]
(precedingEvent)	[Reaction:744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs [Homo sapiens] [Reaction:749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq [Homo sapiens] [Reaction:825631] Glucagon:GCGR mediates GTP-GDP exchange [Homo sapiens] [Reaction:9660828] ADORA2B:Ade-Rib binds heterometric G-protein Gs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790599] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v33:[modifyText] [_UpdateTracker:9791497] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v29:[addLiteratureReference, add_removeSummation] [_UpdateTracker:9846854] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v83:[add_removeInput, modifyText] [_UpdateTracker:9864310] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v88:[addCatalystActivity]
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