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Details on Person UniProt:Q96FJ2 DYNLL2
| Class:Id | ReferenceGeneProduct:163349 |
|---|---|
| _chainChangeLog | chain:1-89 added on Sat February 7 2015 |
| _displayName | UniProt:Q96FJ2 DYNLL2 |
| _timestamp | 2024-11-03 19:36:09 |
| chain | chain:1-89 |
| checksum | 45364D32C0077F8E |
| comment | FUNCTION Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).SUBUNIT Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition (By similarity). The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits (By similarity). Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer (By similarity). Interacts with DYNC1I1 (By similarity). Interacts with BMF (By similarity). Component of the myosin V motor complex (By similarity). Interacts with BCAS1 (By similarity). Interacts with Basson/BSN (PubMed:19380881). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (PubMed:20921139). Interacts with IQUB (By similarity).INTERACTION Belongs to the dynein light chain family. |
| created | [InstanceEdit:163342] Gopinathrao, G, 2005-04-27 17:36:27 |
| description | recommendedName: Dynein light chain 2, cytoplasmic alternativeName: 8 kDa dynein light chain b shortName: DLC8b alternativeName: Dynein light chain LC8-type 2 |
| geneName | DYNLL2 DLC2 |
| identifier | Q96FJ2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Cytoskeleton Dynein Microtubule Motor protein Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DYNLL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000023] ENSEMBL:ENSG00000264364 DYNLL2 [Homo sapiens] |
| secondaryIdentifier | DYL2_HUMAN B2R5B4 |
| sequenceLength | 89 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:140527] DYNLL2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2029024] DYNLL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5624865] DYNLL2 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:5625337] DYNLL2 [ciliary tip] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96FJ2 DYNLL2 (163349)
