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Details on Person Association of MTERF1 (mTERF) with the termination sequence
Class:Id Reaction:163320
_displayName Association of MTERF1 (mTERF) with the termination sequence
_doRelease TRUE
_timestamp 2026-04-22 21:47:57
authored [InstanceEdit:163227] Gustafsson, C, 2005-04-25 22:00:00
compartment [Compartment:5460] mitochondrial matrix
created [InstanceEdit:163319] Matthews, L, 2005-04-27 08:50:28
edited [InstanceEdit:165108] Matthews, L, 0000-00-00 00:00:00
input [EntityWithAccessionedSequence:163275] MTERF1 [mitochondrial matrix] [Homo sapiens] [GenomeEncodedEntity:9985677] mitochondrial DNA terminator [mitochondrial matrix] [Homo sapiens]
literatureReference [LiteratureReference:9985736] Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription [LiteratureReference:9986200] In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions [LiteratureReference:163255] Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination [LiteratureReference:163265] Molecular characterization of the transcription termination factor from human mitochondria [LiteratureReference:164553] The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions [LiteratureReference:164547] Human mitochondrial transcription termination exhibits RNA polymerase independence and biased bipolarity in vitro [LiteratureReference:9986349] Base Flipping by MTERF1 Can Accommodate Multiple Conformations and Occurs in a Stepwise Fashion
modified [InstanceEdit:164198] Matthews, L, 2005-05-12 20:49:46 [InstanceEdit:164227] Matthews, L, 2005-05-12 21:52:46 [InstanceEdit:164538] Matthews, L, 2005-05-26 13:44:21 [InstanceEdit:164570] Matthews, L, 2005-05-26 22:21:24 [InstanceEdit:164593] D'Eustachio, P, 2005-06-02 15:10:56 [InstanceEdit:3168186] D'Eustachio, P, 2013-02-24 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9912770] May, Bruce, 2024-06-10 [InstanceEdit:9985739] May, Bruce, 2026-03-25 [InstanceEdit:9986209] May, Bruce, 2026-03-27 [InstanceEdit:9986217] May, Bruce, 2026-03-27 [InstanceEdit:9986220] May, Bruce, 2026-03-27 [InstanceEdit:9986361] May, Bruce, 2026-03-30 [InstanceEdit:9987659] May, Bruce, 2026-04-22
name Association of MTERF1 (mTERF) with the termination sequence
output [Complex:163321] MTERF1:mitochondrial transcription termination sequence [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars
releaseDate 2005-06-13
reviewed [InstanceEdit:165107] Cantatore, P, 0000-00-00 00:00:00 [InstanceEdit:9986218] May, Bruce, 2026-03-27
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:359844] R-HSA-163320.4
structureModified [InstanceEdit:9986217] May, Bruce, 2026-03-27
summation [Summation:163317] The 39-kDa mitochondrial transcription termination factor (M...
(hasEvent) [Pathway:163316] Mitochondrial transcription termination [Homo sapiens] [Pathway:9985686] Mitochondrial transcription [Homo sapiens]
(precedingEvent) [Reaction:9986199] TEFM:POLRMT:mitochondrial genome:H,L strand transcript contacts MTERF1 [Homo sapiens]
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